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Ziv-aflibercept in metastatic colorectal cancer

Authors Patel A, Sun W

Received 1 October 2013

Accepted for publication 12 November 2013

Published 16 December 2013 Volume 2014:8 Pages 13—25

DOI https://doi.org/10.2147/BTT.S39360

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Anuj Patel, Weijing Sun

Division of Hematology-Oncology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

Abstract: The combination of cytotoxic chemotherapy and antiangiogenic agents has become a conventional treatment option for patients with metastatic colorectal cancer. Ziv-aflibercept is a fusion protein which acts as a decoy receptor for vascular endothelial growth factor (VEGF)-A, VEGF-B, and placental growth factor (PlGF); it was approved in combination with 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) for the treatment of patients with metastatic colorectal cancer that is resistant to or has progressed after an oxaliplatin-containing fluoropyrimidine-based regimen. Herein we review the role of tumor angiogenesis as the rationale for antiangiogenic therapy, the clinical data associated with ziv-aflibercept, and its current role as a treatment option compared to other antiangiogenic agents, such as bevacizumab and regorafenib.

Keywords: aflibercept, angiogenesis, colorectal cancer

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