Back to Journals » Therapeutics and Clinical Risk Management » Volume 4 » Issue 5

Weekly docetaxel in the treatment of metastatic breast cancer

Authors Laura Palmeri, Marina Vaglica, Sergio Palmeri

Published 10 October 2008 Volume 2008:4(5) Pages 1047—1059

DOI https://doi.org/10.2147/TCRM.S3397

Review by Single-blind

Peer reviewer comments 3

Laura Palmeri, Marina Vaglica, Sergio Palmeri

Department of Oncology, University of Palermo, Palermo, Italy

Abstract: Breast cancer is the most frequent tumor among women worldwide and is the second cause of cancer-related mortality in the US. Metastatic breast cancer (MBC) accounts for less than 10% of newly diagnosed breast cancer patients and about 30% of early breast cancer patients will develop recurrent, advanced, or metastatic disease. It remains an incurable illness and the primary goal of its management is palliative. Several agents are active for the first-line treatment of MBC. The taxanes, paclitaxel and docetaxel, represent the standard of care for the treatment of these patients. Among the various schedules, docetaxel can be administered weekly, achieving similar efficacy results with lower toxicity compared with conventional schedules. Weekly docetaxel (25–40 mg/m2) has been widely tested in several phase I and II studies both as a single agent and in multichemotherapy regimens, reaching overall response rates ranging from 26% and 86% or 20% and 73% with docetaxel alone or in combination, respectively, depending on doses, associations, and line of treatment. Overall, published data support the administration of weekly docetaxel for the treatment of MBC patients even if data from phase III randomized trials are still lacking.

Keywords: docetaxel, weekly, metastatic breast cancer, chemotherapy

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 

 

Readers of this article also read:

The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats

Rouhollahi E, Moghadamtousi SZ, Al-Henhena N, Kunasegaran T, Hasanpourghadi M, Looi CY, Abd Malek SN, Awang K, Abdulla MA, Mohamed Z

Drug Design, Development and Therapy 2015, 9:3911-3922

Published Date: 27 July 2015

Central airways remodeling in COPD patients

Pini L, Pinelli V, Modina D, Bezzi M, Tiberio L, Tantucci C

International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:927-933

Published Date: 1 September 2014

P-wave indices in patients with pulmonary emphysema: do P-terminal force and interatrial block have confounding effects?

Chhabra L, Chaubey VK, Kothagundla C, Bajaj R, Kaul S, Spodick DH

International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:245-250

Published Date: 14 May 2013

Supramolecular micellar nanoaggregates based on a novel chitosan/vitamin E succinate copolymer for paclitaxel selective delivery

Lian H, Sun J, Yu YP, Liu YH, Cao W, Wang YJ, Sun YH, Wang SL, He ZG

International Journal of Nanomedicine 2011, 6:3323-3334

Published Date: 12 December 2011

Adjusting for COPD severity in database research: developing and validating an algorithm

Goossens LMA, Baker CL, Monz BU, Zou KH, Rutten-van Mölken MPMH

International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:669-678

Published Date: 6 December 2011

Acute whiplash associated disorders (WAD)

Pastakia K, Kumar S

Open Access Emergency Medicine 2011, 3:29-32

Published Date: 27 April 2011

Theory of planned behavior and smoking: meta-analysis and SEM model

Gabriela Topa, Juan Antonio Moriano

Substance Abuse and Rehabilitation 2010, 1:23-33

Published Date: 6 December 2010

Teriparatide in the management of osteoporosis

Donald Bodenner, Carolyn Redman, Ann Riggs

Clinical Interventions in Aging 2007, 2:499-507

Published Date: 15 January 2008