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Vulnerability or resilience of motopsin knockout mice to maternal separation stress depending on adulthood behaviors

Authors Hidaka C, Kashio T, Uchigaki D, Mitsui S

Received 5 April 2018

Accepted for publication 4 July 2018

Published 4 September 2018 Volume 2018:14 Pages 2255—2268

DOI https://doi.org/10.2147/NDT.S170281

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Prof. Dr. Roumen Kirov

Peer reviewer comments 2

Editor who approved publication: Dr Taro Kishi


Chiharu Hidaka,1,2 Taiki Kashio,1 Daiju Uchigaki,3 Shinichi Mitsui1,3

1Department of Rehabilitation Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Japan; 2Department of Neurobiology and Anatomy, Kochi Medical School, Kochi University, Nankoku, Japan; 3Department of Occupational Therapy, Gunma University, Maebashi, Japan

Background: Both environmental and genetic conditions contribute to the robust development of neuronal circuits and adulthood behaviors. Loss of motopsin gene function causes severe intellectual disability in humans and enhanced social behavior in mice. Furthermore, childhood maltreatment is a risk factor for some psychiatric disorders, and children with disabilities have a higher risk of abuse than healthy children.
Materials and methods: In this study, we investigated the effects of maternal separation (MS) on adulthood behaviors of motopsin knockout (KO) and wild-type (WT) mice.
Results: The MS paradigm decreased the duration that WT mice stayed in the center area of an open field, but not for motopsin KO mice; however, it decreased the novel object recognition index in both genotypes. In the marble burying test, motopsin KO mice buried fewer marbles than WT mice, regardless of the rearing conditions. The MS paradigm slightly increased and reduced open arm entry in the elevated plus maze by WT and motopsin KO mice, respectively. In the three-chamber test, the rate of sniffing the animal cage was increased by the MS paradigm only for motopsin KO mice. After the three-chamber test, motopsin KO mice had fewer cFos-positive cells in the prelimbic cortex, which is involved in emotional response, than WT mice. In the infralimbic cortex, the MS paradigm decreased the number of cFos-positive cells in motopsin KO mice.
Conclusion: Our results suggest that motopsin deficiency and childhood adversity independently affect some behaviors, but they may interfere with each other for other behaviors. Defective neuronal circuits in the prefrontal cortex may add to this complexity.

Keywords:
early-life stress, mental retardation, neurotrypsin, PFC, PRSS12

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