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Volasertib for AML: clinical use and patient consideration
Authors Hao Z, Kota V
Received 8 May 2015
Accepted for publication 22 June 2015
Published 17 July 2015 Volume 2015:8 Pages 1761—1771
DOI https://doi.org/10.2147/OTT.S60762
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Ru Chen
Peer reviewer comments 3
Editor who approved publication: Professor Daniele Santini
Zhonglin Hao,1 Vamsi Kota2
1Cancer Center, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA; 2Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
Abstract: Acute myeloid leukemia (AML) is a disease diagnosed mostly in patients >65 years of age. Despite its heterogeneous nature, the different types of AMLs are still managed by standard induction chemotherapy for those who can tolerate it in the beginning. For the elderly and infirm patients, however, this approach leads to unacceptably high induction mortality rate. This article reviews past and current efforts searching for low-intensiveness treatments for the elderly and infirm patients who cannot tolerate the standard induction regimen. Volasertib, currently in Phase III clinical trials in combination with cytarabine, is reviewed as a promising agent for this patient population with AML, from the viewpoints of potential compliance and efficacy.
Keywords: volasertib, acute myeloid leukemia, management, induction
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