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Vitiligo and Rise in Blood Pressure – a Case–Control Study in a Referral Dermatology Clinic in Southern Iran

Authors Namazi MR, Rouhani S, Moarref A, Kiani M, Tabei SS, Hadibarhaghtalab M

Received 5 April 2020

Accepted for publication 15 June 2020

Published 22 June 2020 Volume 2020:13 Pages 425—430

DOI https://doi.org/10.2147/CCID.S257022

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg


Mohammad Reza Namazi,1 Shekoofe Rouhani,2 Alireza Moarref,2 Mahsa Kiani,1 Seyed Sajjad Tabei,3 Maryam Hadibarhaghtalab1

1Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; 2Cardiology Department, Shiraz University of Medical Sciences, Shiraz, Iran; 3Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Correspondence: Maryam Hadibarhaghtalab
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Tel +98 917 101 7912
Email Maryam_hadibarhaghtalab@yahoo.com

Purpose: Vitiligo is an acquired hypopigmentation condition in which well-defined macules can develop virtually everywhere on the patients’ skin. This analytic case–control study was conducted in Faghihi Hospital outpatient dermatology clinic, affiliated to Shiraz University of Medical Sciences, southern Iran from June to September 2019. Furthermore, we studied the relationship of hypertension with activity, age of onset, duration, affected body surface area and type of vitiligo.
Patients and Methods: In the current case–control study, 166 individuals were enrolled in total (the case group was comprised of 83 vitiligo patients and 83 individuals actedas control group). The case group was made up of vitiligo patients (both segmental and non-segmental) between 20 and 50 years of age, no prior history of systemic disease and other hypopigmentation disorders, while individuals with any form of dermatologic findings were excluded from the control group. Individuals aged younger than 20 years old or older than 50, having a dermatologic disease other than vitiligo, being afflicted with the diseases which may lead to secondary hypertension, pregnancy, taking substances, and medication which can lead to hypertension were chosen as the exclusion criteria in this study.
Results: Data obtained from our study revealed that vitiligo patients had a higher prevalence of essential hypertension diagnosis than the control group (P=0.040). Also, no significant relationship was found between patients’ age at the first lesion appearance (P=0.856), duration of vitiligo involvement (P=0.497), and percentage of vitiligo involvement (P=0.681) with hypertension.
Conclusion: According to our results, vitiligo patients were more susceptible to hypertension while no association could be found between characteristics of the disease and rise in blood pressure.

Keywords: vitiligo, hypertension, catecholamines, metabolic syndrome

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