Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 6

Vitamin D and responses to inhaled fluticasone in severe chronic obstructive pulmonary disease

Authors Ken M Kunisaki, Thomas S Rector

Published 7 January 2011 Volume 2011:6 Pages 29—34

DOI https://doi.org/10.2147/COPD.S15358

Review by Single-blind

Peer reviewer comments 3

Ken M Kunisaki1,3, Thomas S Rector2,4
1Pulmonary Section, 2Center for Chronic Disease Outcomes Research and Center for Epidemiologic and Clinical Research, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, USA; 3Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, 4Department of Medicine, University of Minnesota, Minneapolis, MN, USA

Background: Patients with chronic obstructive pulmonary disease (COPD) demonstrate variable responses to inhaled corticosteroids (ICS). The factors contributing to this variability are not well understood. Data from patients with asthma have suggested that low 25-hydroxyvitamin D [25(OH)D] levels contribute to a lack of ICS response in asthma. The objective of this study was to determine whether serum levels of 25(OH)D were related to ICS responses in patients with COPD.
Methods: A total of 60 exsmokers with severe COPD (mean forced expiratory volume in one second [FEV1] 1.07 L, 36% of predicted) spent 4 weeks free of any ICS, followed by 4 weeks of ICS use (fluticasone propionate 500 µg twice daily). Spirometry was performed prior to and after 4 weeks of ICS use. Blood 25(OH)D levels were measured prior to ICS use and examined for relationships to changes in FEV1 following the 4 weeks of ICS use.
Results: The mean 25(OH)D level was 23.3 ± 9.3 ng/mL. There was a high prevalence of vitamin D insufficiency (35%) and deficiency (40%). There was no relationship between baseline 25(OH)D and changes in FEV1 following 4 weeks of ICS.
Conclusion: Baseline 25(OH)D does not contribute to the variation in short-term FEV1 responses to ICS in patients with severe COPD.

Keywords: COPD, androstadienes, anti-inflammatory agents, spirometry

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other article by this author:

Supplemental vitamin D and physical performance in COPD: a pilot randomized trial

Bjerk SM, Edgington BD, Rector TS, Kunisaki KM

International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:97-104

Published Date: 15 February 2013

Readers of this article also read:

Pain management in patients with dementia

Achterberg WP, Pieper MJC, van Dalen-Kok AH, de Waal MWM, Husebo BS, Lautenbacher S, Kunz M, Scherder EJA, Corbett A

Clinical Interventions in Aging 2013, 8:1471-1482

Published Date: 1 November 2013

Safety of indacaterol in the treatment of patients with COPD

Donohue JF, Singh D, Kornmann O, Lawrence D, Lassen C, Kramer B

International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:477-492

Published Date: 22 September 2011

Long-term azithromycin therapy in patients with severe COPD and repeated exacerbations

Pomares X, Montón C, Espasa M, Casabon J, Monsó E, Gallego M

International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:449-456

Published Date: 6 September 2011

A novel study design for antibiotic trials in acute exacerbations of COPD: MAESTRAL methodology

Wilson R, Anzueto A, Miravitlles M, Arvis P, Faragó G, Haverstock D, Trajanovic M, Sethi S

International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:373-383

Published Date: 29 June 2011

Barriers to adherence to chronic obstructive pulmonary disease guidelines by primary care physicians

Gregory D Salinas, James C Williamson, Ravi Kalhan, et al

International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:171-179

Published Date: 28 February 2011