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Visual outcomes of age-related macular degeneration patients undergoing intravitreal ranibizumab monotherapy in an urban population

Authors Basheer K, Mensah E, Khanam T, Minakaran N

Received 1 November 2014

Accepted for publication 27 March 2015

Published 28 May 2015 Volume 2015:9 Pages 959—965

DOI https://doi.org/10.2147/OPTH.S76754

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Khadijah Basheer, Evelyn Mensah, Tina Khanam, Neda Minakaran

Ophthalmology Department, Central Middlesex Hospital, London, UK

Aim: To compare the visual outcomes of an urban population with age-related macular degeneration (AMD) undergoing ranibizumab monotherapy to the results from major clinical trials.
Procedures: Prospective data was collected from 164 wet AMD patients receiving intravitreal ranibizumab. Visual acuities were obtained with the Early Treatment Diabetic Retinopathy Study chart. All patients underwent a loading phase of three monthly treatments of ranibizumab. Patients were monitored monthly using a retreatment criterion. Treatment was further individualized by sequentially lengthening follow-up intervals when stable.
Results: At 12 and 24 months, respectively, the percentage of eyes that maintained vision was 91% and 88.6%. We found that 20.3% of eyes had improved vision at 12 months and 20% at 24 months. At 12 months, 8.3% of eyes’ vision worsened and 12% worsened at 24 months.
Conclusion: Individualized ranibizumab monotherapy is effective in preserving vision in wet AMD and follows the same trends as the pivotal trials.

Keywords: visual acuity, comparison of age-related macular degeneration treatment trials, choroidal neovascular membrane

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