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Visual field defects and changes in macular retinal ganglion cell complex thickness in eyes with intrachoroidal cavitation are similar to those in early glaucoma

Authors Okuma S, Mizoue S, Ohashi Y

Received 9 December 2015

Accepted for publication 23 March 2016

Published 29 June 2016 Volume 2016:10 Pages 1217—1222


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

Shinichi Okuma,1 Shiro Mizoue,2,3 Yuichi Ohashi3

1Department of Ophthalmology, Sumitomo Besshi Hospital, Niihama-shi, 2Department of Ophthalmology, Minami-Matsuyama Hospital, Matsuyama-shi, 3Department of Ophthalmology, Ehime University School of Medicine, Toon-shi, Ehime, Japan

Background/aims: To examine the characteristics of visual field defects and optical coherence tomography (OCT) findings in eyes with intrachoroidal cavitation (ICC) and investigate the similarities between these results and glaucomatous changes.
Methods: We retrospectively analyzed patients diagnosed with ICC based on peripapillary radial cross-sectional scans performed with OCT. Visual field was measured with the Humphrey automated visual field analyzer SITA standard central 24-2 program, and macular ganglion cell complex (GCC) thickness was measured in 9×9 mm areas on OCT. The positive rates for the Anderson criteria, site of visual field defect, and mean GCC thickness in each quadrant were compared; the association between these results and ICC location was assessed.
Results: Fifteen eyes from eleven patients (five males and six females; mean age, 54.6±10.7 years) were selected for investigation. ICC was detected in the inferior temporal side of the optic disc in all studied eyes. The positive rate for the Anderson criteria was 73.3% (11/15 eyes). Visual field defects were most commonly observed in the cluster that corresponded to the superior Bjerrum area (53.3%; 8/15 eyes). GCC thickness was significantly lower in the inferior side, where the ICC was located, than the superior side, where the ICC was absent (P=0.0001). GCC thinning that correlated with ICC was observed in 66.7% (10/15 eyes) of the ICC eyes.
Conclusion: Visual field and GCC findings on OCT in ICC eyes are extremely similar to those observed in superior visual field defect-type early glaucoma, indicating a possible difficulty in distinguishing the two conditions.

Keywords: intrachoroidal cavitation, visual field, ganglion cell complex, glaucoma

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