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Visual field characteristics in neuromyelitis optica in absence of and after one episode of optic neuritis

Authors Merle H, Olindo S, Jeannin S, Hage R, Donnio A, Richer R, Cabre P

Received 11 February 2013

Accepted for publication 19 April 2013

Published 11 June 2013 Volume 2013:7 Pages 1145—1153

DOI https://doi.org/10.2147/OPTH.S43894

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Harold Merle,1 Stéphane Olindo,2 Séverine Jeannin,2 Rabih Hage,1 Angélique Donnio,1 Raymond Richer,1 Philippe Cabre2

1Service d'Ophtalmologie, 2Service de Neurologie, Centre Hospitalier Universitaire de Fort de France, Fort-de-France, Martinique, France

Purpose: Optic neuritis (ON) observed during neuromyelitis optica (NMO) is in most cases very severe and with poor prognosis. This study's objective was to analyze visual field (VF) abnormalities observed in the absence of ON and post-ON episode.
Methods: Twenty-seven cases of both NMO and multiple sclerosis (MS) were selected. Thorough ophthalmologic exam was performed at least 6 months post-ON attack. The VF was collected using the Humphrey 750 perimeter. We used the central threshold tests 24-2 with FASTPAC strategy. The abnormalities were categorized based on the Optic Neuritis Treatment Trial classification.
Results: After one ON, 40% of the NMO group's eyes showed total VF loss (P = 0.01), 21% showed abnormalities of neurologic aspect, and 27% showed fascicular abnormalities of which 12% were altitudinal. Given the total VF loss, the positive predictive value in favor of an NMO was 92.8% and the negative predictive value was 47.3%.
Conclusion: Alterations of the VF during the NMO differ from those observed in the course of the MS. One ON, blinding from the first attack, must call to mind an NMO. The altitudinal deficits point to a vascular mechanism.

Keywords: optic neuritis, visual field, neuromyelitis optica, multiple sclerosis

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