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Visual and subjective outcomes of phototherapeutic keratectomy after Descemet’s stripping endothelial keratoplasty

Authors Lee B, Hardten D

Received 12 March 2014

Accepted for publication 10 April 2014

Published 20 May 2014 Volume 2014:8 Pages 1011—1015

DOI https://doi.org/10.2147/OPTH.S63982

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Bryan S Lee,1,2 David R Hardten2

1Department of Ophthalmology, University of Washington, Seattle, WA, 2Minnesota Eye Consultants, Minneapolis, MN, USA


Background: Patients with endothelial disease also often have scarring or surface corneal disease. This study examined the outcomes of phototherapeutic keratectomy (PTK) performed in patients with prior Descemet’s stripping endothelial keratoplasty (DSEK).
Methods: This retrospective case series examined all patients undergoing PTK after DSEK in a single private practice. The primary outcome was best-corrected visual acuity, with secondary outcomes of change in spherical equivalent versus targeted change, change in endothelial cell count, improvement in corneal topography, and subjective satisfaction with vision.
Results: For the ten patients who met the inclusion criteria, mean best-corrected visual acuity improved from logarithm of the minimum angle of resolution (logMAR) 0.43 to 0.36 (P=0.24) at the most recent postoperative visit. PTK treatments that included a refractive component showed good predictability of 1.13 diopters spherical equivalent/diopter attempted. There was no evidence of a decrease in endothelial cell count from PTK, even with the use of mitomycin C (P=0.95). Subjectively, 80% of patients noted improvement in their vision.
Conclusion: PTK after DSEK has the potential to improve patients’ vision with high levels of patient satisfaction, even though many patients had significant ocular comorbidities. Surgeons should consider using PTK to treat anterior corneal pathology following DSEK.

Keywords: phototherapeutic keratectomy, Descemet’s stripping endothelial keratoplasty, anterior basement membrane dystrophy, irregular astigmatism

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