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Visceral Adiposity Index and Chronic Kidney Disease in a Non-Diabetic Population: A Cross-Sectional Study

Authors Xiao H, Xiong C, Shao X, Gao P, Chen H, Ning J, Chen Y, Zou Z, Hong G, Li X, You X, Sheng J, Wu F, Wang X, Zou H

Received 28 September 2019

Accepted for publication 15 January 2020

Published 4 February 2020 Volume 2020:13 Pages 257—265

DOI https://doi.org/10.2147/DMSO.S231656

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Antonio Brunetti


Hua Xiao,* Chongxiang Xiong,* Xiaofei Shao,* Peichun Gao, Haishan Chen, Jing Ning, Yunying Chen, Ziliang Zou, Guobao Hong, Xiaolin Li, Xu You, Jieli Sheng, Fan Wu, Xin Wang, Hequn Zou

Department of Nephrology, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510630, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Hequn Zou
Department of Nephrology, The Third Affiliated Hospital, Southern Medical University, 183, Zhongshan West Avenue, Tianhe District, Guangzhou 510630, People’s Republic of China
Tel +86 20 6278 4391
Email hequnzou@hotmail.com

Purpose: To investigate the correlation between visceral obesity and pathogenesis of chronic kidney disease (CKD) among non-diabetic individuals, and to evaluate the potential of visceral adiposity index (VAI) as a predictor of CKD.
Patients and Methods: From December 2017 to March 2018, 1877 non-diabetic participants (male n=699, female n=1208) in southern China were recruited for a cross-sectional survey. Males and females were divided into four groups according to gender-specific quartiles of VAI scores. A logistic regression model was established to analyze the correlation between visceral adiposity index and CKD.
Results: Visceral adiposity index was positively correlated with CKD and was negatively associated with estimated glomerular filtration rate (eGFR). Using group one as the control, odds ratios (ORs) were calculated to determine the risk of developing CKD as VAI increased (male: group four 2.73 [P< 0.005]; female: Group three 1.76 [P< 0.05], Group four 2.88 [P< 0.005]). When related factors such as history of hypertension, smoking, alcohol use, and physical inactivity were normalized in the logistic model before calculation, ORs became 2.73 (male: P< 0.05), and 2.18 (female: P< 0.05), respectively. The results differed after normalizing further for systolic blood pressure (SBP), diastolic blood pressure (DBP), hypersensitive c-reactive protein (hsCRP), interleukin-6 (IL-6), homocysteine (Hcy), superoxide dismutase (SOD), and retinol-binding protein (RBP). There were no significant differences in ORs among the female groups.
Conclusion: Visceral adiposity index was significantly associated with CKD in non-diabetic individuals. It may be a good predictor of the pathogenesis of CKD and was dependent on hsCRP, IL-6, Hcy, SOD, RBP, and blood pressure levels in females and males with VAI scores of 1.41 and higher. Visceral adiposity index may be used to predict CKD in males with VAI less than 0.983.

Keywords: visceral adiposity index, chronic kidney disease, non-diabetic population

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