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Vascular effects of rapid-acting insulin analogs in the diabetic patient: a review

Authors Fordan S, Raskin P

Published 19 February 2009 Volume 2009:5 Pages 225—231

DOI https://doi.org/10.2147/VHRM.S3402

Review by Single-blind

Peer reviewer comments 2


Steve Fordan, Philip Raskin

Department of Medicine, Division, of Endocrinology, University of Texas, Southwestern Medical Center, Dallas, TX, USA

Abstract: The insulin analogs lispro, aspart, and glulisine are the only commercially available rapid-acting insulins to treat diabetes. We review the evidence for treating hyperglycemia, using insulin, and specifically using rapid-acting analogs in diabetic individuals, on the prevention of vascular events. We review the beneficial effects of insulin on the vascular system, which include vasodilation and anti-inflammatory actions. The effects of treating hyperglycemia and intensive blood glucose control on vascular outcomes are reviewed.

Keywords: lispro, aspart, glulisine, nitric oxide synthetase, nuclear factor kappa B

 

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