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Validation and Comparison of a Modified Elixhauser Index for Predicting In-Hospital Mortality in Italian Internal Medicine Wards

Authors De Giorgi A, Di Simone E, Cappadona R, Boari B, Savriè C, López-Soto PJ, Rodríguez-Borrego MA, Gallerani M, Manfredini R, Fabbian F

Received 29 January 2020

Accepted for publication 7 April 2020

Published 20 May 2020 Volume 2020:13 Pages 443—451


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Kent Rondeau

Alfredo De Giorgi,1 Emanuele Di Simone,1 Rosaria Cappadona,2 Benedetta Boari,1 Caterina Savriè,1 Pablo J López-Soto,3 María A Rodríguez-Borrego,3 Massimo Gallerani,1 Roberto Manfredini,2 Fabio Fabbian2

1Department of Internal Medicine, University Hospital St. Anna, Ferrara, Italy; 2Department of Medical Sciences, Faculty of Medicine, Pharmacy and Prevention, University of Ferrara, Ferrara, Italy; 3Department of Nursing, Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/University of Córdoba, Córdoba, Spain

Correspondence: Fabio Fabbian
Clinica Medica Unit, Department of Medical Sciences, University of Ferrara, via Fossato di Mortara, Ferrara 46– 44124, Italy
Tel +39 0532 237071
Fax +39 0532 236816

Purpose: Burden of comorbidities appears to be related to clinical outcomes in hospitalized patients. Clinical stratification of admitted patients could be obtained calculating a comorbidity score, which represents the simplest way to identify the severity of patients’ clinical conditions and a practical approach to assess prevalent comorbidities. Our aim was to validate a modified Elixhauser score for predicting in-hospital mortality (IHM) in internal medicine admissions and to compare it with a different one derived from clinical data previously used in a similar setting, having a good prognostic accuracy.
Patients and Methods: A single-center retrospective study enrolled all patients admitted to internal medicine department between January and June 2016. A modified Elixhauser score was calculated from chart review and administrative data; moreover, a second prognostic index was calculated from chart review only. Comorbidity scores were compared using c-statistic.
Results: We analyzed 1614 individuals without selecting the reason for admission, 224 (13.9%) died during hospital stay. Deceased subjects were older (83.3± 9.1 vs 78.4± 13.5 years; p< 0.001) and had higher burden of comorbidities. The modified Elixhauser score calculated by administrative data and by chart review and the comparator one was 18.13± 9.36 vs 24.43± 11.27 vs 7.63± 3.3, respectively, and the c-statistic was 0.758 (95% CI 0.727– 0.790), 0.811 (95% CI 0.782– 0.840) and 0.740 (95% CI 0.709– 0.771), respectively.
Conclusion: The new modified Elixhauser score showed a similar performance to a previous clinical prognostic index when it was calculated using administrative data; however, its performance improved if calculation was based on chart review.

Keywords: in-hospital mortality, internal medicine wards, comorbidity score, validation

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