Back to Journals » International Journal of Women's Health » Volume 4

Vaginal rings for delivery of HIV microbicides

Authors Malcolm K, Fetherston, McCoy, Boyd, Major

Received 31 August 2012

Accepted for publication 16 October 2012

Published 20 November 2012 Volume 2012:4 Pages 595—605

DOI https://doi.org/10.2147/IJWH.S36282

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


R Karl Malcolm, Susan M Fetherston, Clare F McCoy, Peter Boyd, Ian Major

School of Pharmacy, Queen's University Belfast, Belfast, UK

Abstract: Following the successful development of long-acting steroid-releasing vaginal ring devices for the treatment of menopausal symptoms and contraception, there is now considerable interest in applying similar devices to the controlled release of microbicides against HIV. In this review article, the vaginal ring concept is first considered within the wider context of the early advances in controlled-release technology, before describing the various types of ring device available today. The remainder of the article highlights the key developments in HIV microbicide-releasing vaginal rings, with a particular focus on the dapivirine ring that is presently in late-stage clinical testing.

Keywords: controlled release, sustained release, antiretroviral, dapivirine, SILCS diaphragm, silicone elastomer, thermoplastic

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]