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Vaccines for metabolic diseases: current perspectives

Authors Morais T, Andrade S, Pereira S, Monteiro M

Received 13 May 2014

Accepted for publication 23 June 2014

Published 2 September 2014 Volume 2014:4 Pages 55—72

DOI https://doi.org/10.2147/VDT.S47623

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Tiago Morais, Sara Andrade, Sofia S Pereira, Mariana P Monteiro

Department of Anatomy, Unit for Multidisciplinary Biomedical Research, Institute for Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal

Abstract: Several metabolic disorders, such as diabetes, hypertension, dyslipidemia, and obesity, represent significant risk factors for cardiovascular disease, which is the leading cause of morbidity and mortality among adult populations in western societies. Understandably, these chronic disorders have now replaced infectious diseases as the most important public health problem and economic burden to society in most countries. Treatment of metabolic risk factors in order to prevent cardiovascular disease requires an enduring approach with multiple drugs, which can be associated with considerable costs, side effects, and a low rate of therapeutic compliance due to lack of symptoms until later stages of the disease. Since vaccines have proven to be a powerful and effective approach to preventing infectious diseases, attempts to expand the therapeutic use of vaccines into the context of highly prevalent diseases has been attracting increased research interest. Vaccination strategies for chronic diseases in particular are an exciting area of research, with new treatment targets and strategies on the horizon. This review discusses the development of innovative therapeutic agents, focusing on the use of molecular vaccines for the treatment of common and highly prevalent chronic metabolic disorders, ie, diabetes, hypertension, dyslipidemia, and obesity.

Keywords: vaccines, diabetes, hypertension, dyslipidemia, obesity

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