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Using the laws of thermodynamics to understand how matrix metalloproteinases coordinate the myocardial response to injury

Authors Iyer R, Jung M, Lindsey M

Received 2 June 2015

Accepted for publication 2 September 2015

Published 30 October 2015 Volume 2015:2 Pages 75—82


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Yoshifumi Itoh

Rugmani Padmanabhan Iyer,1 Mira Jung,1 Merry L Lindsey1,2

1Mississippi Center for Heart Research, Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, University of Mississippi, 2Research Service, GV (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, MS, USA

Abstract: Following myocardial infarction (MI), the left ventricle (LV) undergoes a series of molecular, cellular, and functional alterations that are both part of the wound healing response to form a scar in the infarct region and the consequence of that response. Using the laws of thermodynamics as an analogy, we present here three laws for categorizing the post-MI LV remodeling process. The first law is that the LV will attempt to maintain equilibrium and compensate as a way to maximize function, the second law is that remodeling is progressive and unidirectional, and the third law is that the final goal is (ideally, but not always achievable) a stable, equilibrated scar. This comparison helps to define the boundaries of the system, whether it be the infarct zone, the LV, the heart, or the entire body. This review provides an overview for those not directly in the field and establishes a framework to help prioritize future research directions.

Keywords: MMP, remodeling, left ventricle, inflammation, fibrosis, extracellular matrix, proteomics

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