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Usefulness of Blood Parameters for Preliminary Diagnosis of Brucellosis

Authors Akya A, Bozorgomid A, Ghadiri K, Ahmadi M, Elahi A, Mozafari H, Almasi A, Namadi P, Chegenelorestani R

Received 13 January 2020

Accepted for publication 17 March 2020

Published 30 March 2020 Volume 2020:11 Pages 107—113

DOI https://doi.org/10.2147/JBM.S245513

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Martin H Bluth


Alisha Akya,1 Arezoo Bozorgomid,1 Kayghobad Ghadiri,1 Mahnaz Ahmadi,2 Azam Elahi,1 Hadi Mozafari,3 Afshin Almasi,4 Parvin Namadi,2 Roya Chegenelorestani1

1Infectious Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran; 3Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 4Cardiovascular Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Correspondence: Roya Chegenelorestani
Infectious Diseases Research Center, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Tel/Fax +98 8334262252
Email lorestani25@gmail.com

Background: Human brucellosis is a multisystem disease with a wide range of clinical signs which often leads to misdiagnosis and treatment delay. Early diagnosis of this disease can prevent the serious complications and mismanagements. This study aimed to evaluate the hematological parameters with predictive value for the diagnosis of brucellosis.
Methods: In this prospective case–control study which was done during 2015– 2017 in Imam Reza Hospital, Kermanshah Province, west Iran, 100 patients with a confirmed diagnosis of brucellosis (brucellosis group) and 100 healthy individuals (control group) were studied. The hematological parameters, including hemoglobin (Hb), red blood cell (RBC), white blood cell (WBC) count, lymphocyte count, neutrophil count, platelet count (PLTs), mean platelet volume (MPV), platelet distribution width (PDW), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) of both groups were recorded. The data were statistically compared between the brucellosis and the control groups.
Results: The mean age of patients and healthy groups was 44.04 ± 23.11 and 37.92 ± 24.80, respectively (P = 0.062). The WBC, CRP and neutrophil counts were significantly higher in the brucellosis group (P < 0.05). Based on the receiver operating characteristic (ROC) analysis, the sensitivity and specificity were 54% and 66% for the WBC, 45% and 71% for the neutrophil and 65% and 72% for the CRP, respectively. There was no statistically significant difference between the two groups in terms of Hb, RBC, WBC, lymphocyte and platelet count, MPV, PDW and ESR (P > 0.05).
Conclusion: The results of this study indicate that WBC, CRP and neutrophil count can be used as valuable markers in the preliminary diagnosis of brucellosis. However, further researches are required to standardize these parameters for various forms of brucellosis.

Keywords: brucellosis, diagnosis, blood cell count, blood parameters

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