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Urine Glucose Excretion Attenuates the Association Between Lipid Accumulation Product and Serum Uric Acid in Subjects with Prediabetes

Authors Chen J, Liu Y, Guo H, Wang B, Sun Z, Yu J

Received 28 March 2020

Accepted for publication 10 June 2020

Published 30 June 2020 Volume 2020:13 Pages 2297—2305

DOI https://doi.org/10.2147/DMSO.S255908

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Ming-Hui Zou


Juan Chen,1 Yu Liu,2 Haijian Guo,3 Bei Wang,4 Zilin Sun,2 Jiangyi Yu1

1Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 2Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Nanjing, People’s Republic of China; 3Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People’s Republic of China; 4School of Public Health, Southeast University, Nanjing, People’s Republic of China

Correspondence: Jiangyi Yu
Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu 210029, People’s Republic of China
Tel +8613851740582
Email YuJY1961@outlook.com
Zilin Sun
Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Nanjing 210009, Jiangsu, People’s Republic of China
Tel +8613951749490
Email Zilinsun1963@outlook.com

Purpose: Obesity is known to be strongly associated with hyperuricemia. Moreover, the impact of urine glucose excretion (UGE) on serum uric acid (UA) levels has gained much more attention in recent years. Yet concern is raised about whether UGE influences the relationship between obesity and hyperuricemia. The aim of this study was to assess the effect of UGE on the association between lipid accumulation product (LAP), a novel marker of visceral adipose accumulation, and UA in subjects with prediabetes.
Materials and Methods: Data were obtained from a cross-sectional study. A total of 3645 subjects with prediabetes were included in the present study. The separate and joint associations of LAP and UGE with hyperuricemia were examined using logistic regression analyses.
Results: LAP was positively associated with UA in both genders. Subgroup analysis based on UGE revealed that the association was strongest in subjects with low UGE (r = 0.328, p < 0.001), whereas the positive association was weakened, but still remained significant in subjects with moderate and high UGE. High LAP was significantly associated with an increased odds ratio for hyperuricemia after adjustment for potential confounders in the overall population (OR = 2.07, 95% CI: 1.66– 2.58, p < 0.001). However, a downward trend in odds ratios for hyperuricemia was observed across UGE categories. In addition, the joint association analysis confirmed that the relationship between LAP and hyperuricemia was attenuated by UGE.
Conclusion: The positive association between LAP and UA appears to be attenuated by UGE, indicating that promoting UGE may be an effective strategy for controlling UA levels, especially for people with obesity who are at increased risk for hyperuricemia.

Keywords: prediabetes, lipid accumulation product, uric acid, urine glucose excretion

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