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Upregulation of hsa_circRNA_102958 Indicates Poor Prognosis and Promotes Ovarian Cancer Progression Through miR-1205/SH2D3A Axis

Authors Wang G, Zhang H, Li P

Received 6 February 2020

Accepted for publication 1 May 2020

Published 28 May 2020 Volume 2020:12 Pages 4045—4053

DOI https://doi.org/10.2147/CMAR.S248560

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Yong Teng


Guan Wang, 1,* Huijing Zhang, 1,* Peiling Li 2

1Department of Gynecology, Heilongjiang Provincial Hospital, Harbin 150000, People’s Republic of China; 2Department of Gynecology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150000, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Peiling Li
Department of Gynecology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150000, People’s Republic of China
Email peiling_li@sohu.com

Background: Circular RNA (circRNA) is a recently identified member of noncoding RNAs. It has been demonstrated to regulate gene expression post-transcriptionally and play critical roles in tumorigenesis. However, how circRNA regulates ovarian cancer (OC) progression is poorly understood. Previously, hsa_circRNA_102958 was reported to regulate gastric cancer and colorectal cancer development. This study aims to investigate the role of hsa_circRNA_102958 in OC progression.
Materials and Methods: qRT-PCR was used to test gene expression. CCK8 and colony formation assays were used to analyze proliferation. Transwell assay was utilized to determine migration and invasion. Luciferase reporter assay was conducted to test the interaction between hsa_circRNA_102958 and miR-1205.
Results: hsa_circRNA_102958 was upregulated in OC tissues and cell lines. hsa_circRNA_102958 upregulation indicated a poor prognosis in OC patients. Knockdown of hsa_circRNA_102958 significantly suppressed the proliferation, migration and invasion of OC cells and vice versa. hsa_circRNA_102958 was a competing endogenous RNA (ceRNA) for miR-1205. hsa_circRNA_102958 inhibited miR-1205 activity to promote SH2D3A expression. Overexpression of SH2D3A promoted proliferation, migration and invasion of OC cells.
Conclusion: Our data suggest that hsa_circRNA_102958 promotes OC aggravation through regulation of miR-1205/SH2D3A signaling.

Keywords: ovarian cancer, circular RNA, hsa_circRNA_102958, miR-1205, SH2D3A

Corrigendum for this paper has been published

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