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Update on triple therapy for eradication of Helicobacter pylori: current status of the art

Authors Urgesi R, Cianci R, Riccioni ME

Received 18 March 2012

Accepted for publication 30 April 2012

Published 17 September 2012 Volume 2012:5 Pages 151—157

DOI https://doi.org/10.2147/CEG.S25416

Review by Single-blind

Peer reviewer comments 3

Riccardo Urgesi,1 Rossella Cianci,2 Maria Elena Riccioni3

1Gastroenterology and Endoscopy Unit, Viterbo, 2Institute of Internal Medicine, Catholic University of Rome, 3Digestive Endoscopy Unit, Catholic University of Rome, Rome, Italy

Abstract: With the rising prevalence of antimicrobial resistance, the treatment success of standard triple therapy has recently declined to unacceptable levels (ie, 80% or less). Following the failure of conventional triple therapy, novel eradication regimens have been developed including sequential therapy, concomitant quadruple therapy, hybrid (dual-concomitant) therapy, bismuth-containing quadruple therapy, and a therapy with administration of N-acetylcysteine before a culture-guided antibiotic regimen. This article reviews the literature published on Helicobacter pylori eradication in the last year, focusing on the development of alternative strategies for first-, second-, and third-line rescue therapy for the eradication of H. pylori.

Keywords: sequential therapy, quadruple therapy, concomitant therapy, hybrid therapy, N-acetylcysteine

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