Back to Journals » International Journal of General Medicine » Volume 3

Update on transfusion solutions during surgery: review of hydroxyethyl starches 130/0.4

Authors Piazza O, Scarpati G

Published 28 September 2010 Volume 2010:3 Pages 287—295

DOI https://doi.org/10.2147/IJGM.S3495

Review by Single anonymous peer review

Peer reviewer comments 3



Ornella Piazza , Giuliana Scarpati , Rosalba Tufano
Anaesthesia and Intensive Care, University of Naples Federico II, School of Medicine, Naples, Italy

Objectives: Restoration of circulation is crucial in the surgical patient management. Colloids and crystalloids are widely used for blood volume therapy. We reviewed recent trials to evaluate efficacy and safety of hydroxyethyl starch (HES) 130/0.4 during surgery.
Material and methods: A subjective, not systematic, review of literature was performed. Papers were searched to answer questions about efficacy of HES, its impact on coagulation and inflammation and its effects on pulmonary mechanics and renal function.
Conclusions: HES 130/0.4 is effective for volume therapy and is less expensive than human albumin. Its effects on coagulation and renal function are manageable; it may ameliorate pulmonary permeability and reduce inflammation.

Keywords: HES, colloids, volume loading, coagulation, inflammation, surgery, renal function, pulmonary mechanics

Creative Commons License © 2010 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.