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Update on the role of antipsychotics in the treatment of Tourette syndrome

Authors Huys D, Hardenacke, Poppe, Bartsch, Baskin, Kuhn J

Received 30 June 2011

Accepted for publication 29 September 2011

Published 12 March 2012 Volume 2012:8 Pages 95—104

DOI https://doi.org/10.2147/NDT.S12990

Review by Single-blind

Peer reviewer comments 6


Daniel Huys, Katja Hardenacke, Pia Poppe, Christina Bartsch, Burak Baskin, Jens Kuhn

Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany

Head: Prof. Dr. Joachim Klosterkötter

Abstract: Tourette syndrome (TS) is a neuropsychiatric disorder with typical onset in childhood and characterized by chronic occurrence of motor and vocal tics. The disorder can lead to serious impairments of both quality of life and psychosocial functioning, particularly for those individuals displaying complex tics. In such patients, drug treatment is recommended. The pathophysiology of TS is thought to involve a dysfunction of basal ganglia-related circuits and hyperactive dopaminergic innervations. Congruently, dopamine receptor antagonism of neuroleptics appears to be the most efficacious approach for pharmacological intervention. To assess the efficacy of the different neuroleptics available, a systematic, keyword-related search in PubMed (National Library of Medicine, Washington, DC) was undertaken. Much information on the use of antipsychotics in the treatment of TS is based on older data. Our objective was to give an update and therefore we focused on papers published in the last decade (between 2001 and 2011). Accordingly, the present review aims to summarize the current and evidence-based knowledge on the risk-benefit ratio of both first and second generation neuroleptics in TS.

Keywords: Tourette, Tourette syndrome, neuroleptics, antipsychotics

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