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Update on the management of Philadelphia chromosome positive chronic myelogenous leukemia: role of nilotinib

Authors Emole J, Talabi T, Pinilla-Ibarz J

Received 30 August 2015

Accepted for publication 9 November 2015

Published 26 February 2016 Volume 2016:10 Pages 23—31


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amol Kavishwar

Peer reviewer comments 2

Editor who approved publication: Dr Doris Benbrook

Josephine Emole,1 Taiwo Talabi,2 Javier Pinilla-Ibarz1

1Department of Malignant Hematology, 2Moffitt Program for Outreach Wellness Education and Resources, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

Abstract: Chronic myelogenous leukemia (CML) is a pluripotent stem cell disease characterized by the presence of the Philadelphia chromosome and the bcr-abl gene. The discovery of tyrosine kinase inhibitors (TKIs) revolutionized therapy for CML, such that durable response, increased overall survival, and increased progression-free survival of patients in chronic phase CML is now possible. Due to resistance and intolerance to imatinib, there was need for development of second- and third-generation TKIs for the treatment of CML. This review examines the role of nilotinib, an oral second-generation TKI, in the treatment of Philadelphia positive CML. The pharmacology, efficacy, and safety of nilotinib are critically evaluated. Patient-related issues, including tolerance, drug interactions, and quality of life issues are also examined.

Keywords: chronic myelogenous leukemia, nilotinib, tyrosine kinase inhibitor

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