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Update on the clinical utility and practical use of ropivacaine in Chinese patients

Authors Li M, Wan L, Mei W, Tian Y

Received 17 April 2014

Accepted for publication 17 June 2014

Published 9 September 2014 Volume 2014:8 Pages 1269—1276


Checked for plagiarism Yes

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Video abstract presented by Wei Mei

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Man Li, Li Wan, Wei Mei, Yuke Tian

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China

Abstract: We reviewed the Chinese and English literature for efficacy and tolerability data as well as pharmacological properties of ropivacaine in Chinese patients. Ropivacaine is a long-acting amide local anesthetic agent that elicits nerve block via reversible inhibition of sodium ion influx in nerve fibers. The available evidence in the literature on anesthesia practice indicates that ropivacaine produces equally surgical sensory block and postoperative and obstetrics analgesia with good maternal and fetal outcome to those of bupivacaine or levobupivacaine. It appears to be associated with comparable onset, quality, and duration of sensory block, but with a lower incidence or grade of motor block, compared to bupivacaine. The satisfaction of both patients and surgeons is high when ropivacaine is used. Thus, ropivacaine appears to be an important option for regional anesthesia and for the management of postoperative and labor pain, with its enhanced sensorimotor differentiation blockage at lower concentrations and enhanced safety at higher concentrations.

Keywords: local anesthetics, anesthesia, analgesia, pharmacology, efficacy, side effect

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