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Update on the challenges of treating trigeminal neuralgia

Authors Obermann M

Received 12 January 2015

Accepted for publication 18 February 2015

Published 10 April 2015 Volume 2015:5 Pages 11—17

DOI https://doi.org/10.2147/ODRR.S53046

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Lise Aagaard

Mark Obermann

Department of Neurology, University of Duisburg-Essen, Essen, Germany

Abstract: Despite the multitude of treatment options currently available for trigeminal neuralgia, its management remains challenging in a considerable number of patients. The response to any particular treatment can be quite variable interindividually, and personalized treatment options are both resource-consuming and time-consuming. Anticonvulsant drugs, muscle relaxants, and neuroleptic agents are the preferred medical treatment for trigeminal neuralgia. Large placebo-controlled clinical trials are scarce, and no specific established substance has been developed for the treatment of trigeminal neuralgia. Promising new treatment options currently in clinical evaluation are botulinum neurotoxin type A injections and CNV1014802, a novel sodium channel blocker that selectively blocks the Nav1.7 sodium channel. Patients who do not respond to medical therapy may be eligible for more invasive treatment options, such as percutaneous Gasserian ganglion techniques, gamma knife surgery, and microvascular decompression.

Keywords: trigeminal neuralgia, treatment, current, future, options, orphan drugs
 

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