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Update on new biologics for intractable eosinophilic asthma: impact of reslizumab

Authors Sahota J, Robinson DS

Received 19 October 2017

Accepted for publication 31 January 2018

Published 8 May 2018 Volume 2018:12 Pages 1173—1181


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Jianbo Sun

Jagdeep Sahota,1 Douglas S Robinson2

1Department of Respiratory Medicine, University College London, London, UK; 2Department of Respiratory Medicine, University College Hospital NHS Trust, London, UK

Abstract: A small percentage of patients with asthma have uncontrolled symptoms and frequent exacerbations, despite treatment with inhaled corticosteroids and other agents. It has become clear that different subtypes of this severe, treatment-resistant group exist due to different mechanisms of the disease. All such patients require detailed assessment in specialist centers to characterize the disease and assess treatment adherence. Recently, monoclonal antibodies have become available, which target specific pathways that may contribute to persistent inflammation and asthma exacerbations. These antibodies include those targeting interleukin (IL)-5, which drives eosinophilic inflammation. Reslizumab is a newly licensed antibody that blocks binding of IL-5 to its receptor. Here, we discuss the significance of clinical data of this drug, which show up to 50% reduction in exacerbation rates, together with modest but significant improvements in lung function and quality of life, in those with persistent eosinophilia. The combination of reslizumab with mepolizumab and benralizumab, which also target IL-5, may be a useful addition to the therapeutic armamentarium in a selected group of patients with severe asthma.

Keywords: asthma, eosinophil

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