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Update on first-line treatment of advanced ovarian carcinoma

Authors Kemp Z, Ledermann JA

Received 14 November 2012

Accepted for publication 14 December 2012

Published 25 January 2013 Volume 2013:5 Pages 45—51

DOI https://doi.org/10.2147/IJWH.S30231

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Z Kemp,1 JA Ledermann1,2

1Department of Oncology, University College London Hospitals, 2University College London Cancer Institute, University College London, London, United Kingdom

Abstract: Despite the high response rate to first-line treatment of advanced ovarian cancer, the vast majority of patients relapse. Maximal debulking surgery and chemotherapy with a platinum doublet have remained the standard of care for many years and new approaches are imperative. Recent clinical trials have given grounds for hope. Neoadjuvant chemotherapy, intraperitoneal delivery, and dose-dense strategies have all shown promising results, as has the targeting of angiogenesis. A greater understanding of the molecular landscape of ovarian cancer is helping to identify new treatment options. In this review, we will highlight the key trials and recent progress in these areas.

Keywords: ovarian cancer, first-line therapy, neoadjuvant, intraperitoneal, dose-dense, angiogenesis

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