United airway disease: current perspectives
Authors Giavina-Bianchi P, Aun M, Takejima P, Kalil J, Agondi R
Received 4 January 2016
Accepted for publication 22 February 2016
Published 11 May 2016 Volume 2016:9 Pages 93—100
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Prof. Dr. Saeed Kolahian
Peer reviewer comments 2
Editor who approved publication: Dr Amrita Dosanjh
Pedro Giavina-Bianchi,* Marcelo Vivolo Aun,* Priscila Takejima, Jorge Kalil, Rosana Câmara Agondi
Clinical Immunology and Allergy Division, Faculty of Medicine, University of São Paulo, São Paulo, Brazil
*These authors contributed equally to this work.
Abstract: Upper and lower airways are considered a unified morphological and functional unit, and the connection existing between them has been observed for many years, both in health and in disease. There is strong epidemiologic, pathophysiologic, and clinical evidence supporting an integrated view of rhinitis and asthma: united airway disease in the present review. The term “united airway disease” is opportune, because rhinitis and asthma are chronic inflammatory diseases of the upper and lower airways, which can be induced by allergic or nonallergic reproducible mechanisms, and present several phenotypes. Management of rhinitis and asthma must be jointly carried out, leading to better control of both diseases, and the lessons of the Allergic Rhinitis and Its Impact on Asthma initiative cannot be forgotten.
Keywords: ARIA, united airway disease, rhinitis, asthma, allergy, atopy, immediate hypersensitivity reaction, guideline
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