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Ultra-small superparamagnetic particles of iron oxide in magnetic resonance imaging of cardiovascular disease

Authors Stirrat C, Vesey A, McBride O, Robson J, Alam S, Wallace W, Semple S, Henriksen P, Newby D

Received 28 May 2014

Accepted for publication 1 July 2014

Published 3 October 2014 Volume 2014:2 Pages 99—112

DOI https://doi.org/10.2147/JVD.S50036

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Colin G Stirrat,1 Alex T Vesey,1 Olivia MB McBride,1 Jennifer MJ Robson,1 Shirjel R Alam,1 William A Wallace,2 Scott I Semple,1,3 Peter A Henriksen,1 David E Newby1

1British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; 2Department of Pathology, University of Edinburgh, Edinburgh, UK; 3Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, UK

Abstract: Ultra-small superparamagnetic particles of iron oxide (USPIO) are iron-oxide based contrast agents that enhance and complement in vivo magnetic resonance imaging (MRI) by shortening T1, T2, and T2* relaxation times. USPIO can be employed to provide immediate blood pool contrast, or to act as subsequent markers of cellular inflammation through uptake by inflammatory cells. They can also be targeted to specific cell-surface markers using antibody or ligand labeling. This review will discuss the application of USPIO contrast in MRI studies of cardiovascular disease.

Keywords: cardiac, aortic, MRI, USPIO, carotid, vascular, molecular imaging

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