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Two-year results of a community-based randomized controlled lifestyle intervention trial to control prehypertension and/or prediabetes in Thailand: a brief report

Authors Pengpid S, Peltzer K, Jayasvasti I, Aekplakorn W, Puckpinyo A, Nanthananate P, Mansin A

Received 1 January 2019

Accepted for publication 20 February 2019

Published 25 March 2019 Volume 2019:12 Pages 131—135


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

Supa Pengpid,1,2 Karl Peltzer,3,4 Isareethika Jayasvasti,1 Wichai Aekplakorn,5 Apa Puckpinyo,1 Pheeraya Nanthananate,6 Anutsara Mansin7

1ASEAN Institute for Health Development, Mahidol University, Salaya, Thailand; 2Department of Research Development and Innovation, University of Limpopo, Polokwane, South Africa; 3Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam; 4Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam; 5Department of Community Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 6Faculty of Nursing, Bangkok-Thonburi University, Bangkok, Thailand; 7Department Surgical Nursing, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

Abstract: The aim of the study was to assess the 2-year effect of a community-based randomized controlled lifestyle intervention on glucose and blood pressure levels in Thailand. Participants (N=443, with prediabetes and/or prehypertension) received a six 2-hr group sessions lifestyle intervention (physical activity and nutrition) over 6 months. Measurements were at baseline, 12 months (89%) and at 24 months (84.7%). Statistically significant interaction effects on fasting plasma glucose and DBP at 12 months were not maintained at 24 months, while significant interaction effects were found on high-density lipoprotein and low-density lipoprotein cholesterol at 24 months. Improvements were found for fasting plasma glucose, SBP, DBP and total cholesterol, but no significant interaction effect was detected. The development of type 2 diabetes was higher in the control than in the intervention group, but it was not reaching significance (P=0.181), while 3.0% in the intervention group and 2.6% in the control group developed hypertension at 24 months. No significant group differences were found in psycho-behavioral variables. The lifestyle intervention did not provide additional benefits compared to the control group at 24-month follow-up.
Trial registration number: TCTR20170721001

Keywords: community-based intervention, lifestyle intervention, prediabetes, prehypertension, Thailand

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