Back to Journals » OncoTargets and Therapy » Volume 7

Two thymus-related autoimmune disorders: a case report and review of the literature

Authors Mirtavoos-Mahyari H, Khosravi A, Esfahani-Monfared Z, Shadmehr MB

Received 24 November 2013

Accepted for publication 23 January 2014

Published 10 May 2014 Volume 2014:7 Pages 633—636

DOI https://doi.org/10.2147/OTT.S58194

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


Mirtavoos-Mahyari Hanifeh,1 Adnan Khosravi,2 Esfahani-Monfared Zahra,1 Shadmehr Mohammad Behgam3

1Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Tobacco Prevention and Control Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract: Thymoma is the most common tumor in the anterior mediastinum. A 56-year-old man presented unremitting and periodic chronic diarrhea of 9 weeks duration, and clinical examination revealed a huge nonhomogeneous mass lesion in the right lung and leukocytosis. He was treated with CHOP regimen (cyclophosphamide 1,200 mg/m2, doxorubicin 50 mg/m2, vincristine 1.5 mg/m2 and prednisolone 75 mg/m2 × 5 days) based on lung mass computed tomography-guided biopsy, but he was reevaluated because neither symptom improved. Surprisingly, celiac disease was documented with increased titer of immunoglobulin antibodies to gliadin and tissue transglutaminase. Lung mass rebiopsy and thymectomy demonstrated thymoma. After surgery, the patient showed aplastic anemia that responded well to cyclosporine. At 2-year follow-up, the patient’s hematologic status and diarrhea were completely recovered and no symptom and/or sign of thymoma recurrence was seen.

Keywords: thymus, thymoma, celiac, aplastic anemia, autoimmune disorder

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]