Back to Journals » International Journal of Nanomedicine » Volume 10 » Issue 1

Tuning the surface microstructure of titanate coatings on titanium implants for enhancing bioactivity of implants

Authors Wang H, Lai Y, Zheng R, Bian Y, Zhang K, Lin C

Received 17 October 2014

Accepted for publication 3 February 2015

Published 8 June 2015 Volume 2015:10(1) Pages 3887—3896

DOI https://doi.org/10.2147/IJN.S75999

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 6

Editor who approved publication: Dr Lei Yang

Hui Wang,1,2 Yue-Kun Lai,1 Ru-Yue Zheng,1 Ye Bian,1 Ke-Qin Zhang,1 Chang-Jian Lin2

1National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, 2State Key Laboratory for Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, People’s Republic of China

Abstract: Biological performance of artificial implant materials is closely related to their surface characteristics, such as microtopography, and composition. Therefore, convenient fabrication of artificial implant materials with a cell-friendly surface structure and suitable composition was of great significance for current tissue engineering. In this work, titanate materials with a nanotubular structure were successfully fabricated through a simple chemical treatment. Immersion test in a simulated body fluid and in vitro cell culture were used to evaluate the biological performance of the treated samples. The results demonstrate that the titanate layer with a nanotubular structure on Ti substrates can promote the apatite-inducing ability remarkably and greatly enhance cellular responses. This highlights the potential of such titanate biomaterials with the special nanoscale structure and effective surface composition for biomedical applications such as bone implants.

Keywords: nanotubes structure, bone-like apatite, cell culture, biological performance

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]