Back to Journals » International Journal of Nanomedicine » Volume 10 » Issue 1

Tuning the surface microstructure of titanate coatings on titanium implants for enhancing bioactivity of implants

Authors Wang H, Lai YK, Zheng RY, Bian Y, Zhang KQ, Lin CJ

Received 17 October 2014

Accepted for publication 3 February 2015

Published 8 June 2015 Volume 2015:10(1) Pages 3887—3896

DOI https://doi.org/10.2147/IJN.S75999

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 6

Editor who approved publication: Dr Lei Yang

Hui Wang,1,2 Yue-Kun Lai,1 Ru-Yue Zheng,1 Ye Bian,1 Ke-Qin Zhang,1 Chang-Jian Lin2

1National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, 2State Key Laboratory for Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, People’s Republic of China

Abstract: Biological performance of artificial implant materials is closely related to their surface characteristics, such as microtopography, and composition. Therefore, convenient fabrication of artificial implant materials with a cell-friendly surface structure and suitable composition was of great significance for current tissue engineering. In this work, titanate materials with a nanotubular structure were successfully fabricated through a simple chemical treatment. Immersion test in a simulated body fluid and in vitro cell culture were used to evaluate the biological performance of the treated samples. The results demonstrate that the titanate layer with a nanotubular structure on Ti substrates can promote the apatite-inducing ability remarkably and greatly enhance cellular responses. This highlights the potential of such titanate biomaterials with the special nanoscale structure and effective surface composition for biomedical applications such as bone implants.

Keywords: nanotubes structure, bone-like apatite, cell culture, biological performance

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

Compound antimalarial ethosomal cataplasm: preparation, evaluation, and mechanism of penetration enhancement

Shen S, Liu SZ, Zhang YS, Du MB, Liang AH, Song LH, Ye ZG

International Journal of Nanomedicine 2015, 10:4239-4253

Published Date: 30 June 2015

Enzyme-responsive nanocomposites for wound infection prophylaxis in burn management: in vitro evaluation of their compatibility with healing processes

Grützner V, Unger RE, Baier G, Choritz L, Freese C, Böse T, Landfester K, Kirkpatrick CJ

International Journal of Nanomedicine 2015, 10:4111-4124

Published Date: 24 June 2015

Utilization of nanotechnology to enhance percutaneous absorption of acyclovir in the treatment of herpes simplex viral infections

Al-Subaie MM, Hosny KM, El-Say KM, Ahmed TA, Aljaeid BM

International Journal of Nanomedicine 2015, 10:3973-3985

Published Date: 15 June 2015

Mesoporous bioactive glass surface modified poly(lactic-co-glycolic acid) electrospun fibrous scaffold for bone regeneration

Chen SJ, Jian ZY, Huang LS, Xu W, Liu SH, Song DJ, Wan ZM, Vaughn A, Zhan RS, Zhang CY, Wu S, Hu MH, Li JS

International Journal of Nanomedicine 2015, 10:3815-3827

Published Date: 2 June 2015

Efficacy and mechanism of tanshinone IIA liquid nanoparticles in preventing experimental postoperative peritoneal adhesions in vivo and in vitro

Qin F, Ma Y, Li X, Wang X, Wei Y, Hou C, Lin S, Hou L, Wang C

International Journal of Nanomedicine 2015, 10:3699-3717

Published Date: 21 May 2015

Dual-color immunofluorescent labeling with quantum dots of the diabetes-associated proteins aldose reductase and Toll-like receptor 4 in the kidneys of diabetic rats

Liu XM, Hu R, Lian HW, Liu Y, Liu J, Liu JW, Lin GM, Liu LW, Duan XJ, Yong KT, Ye L

International Journal of Nanomedicine 2015, 10:3651-3662

Published Date: 20 May 2015

Application of dental nanomaterials: potential toxicity to the central nervous system

Feng X, Chen A, Zhang Y, Wang J, Shao L, Wei L

International Journal of Nanomedicine 2015, 10:3547-3565

Published Date: 14 May 2015

Photoactive TiO2 antibacterial coating on surgical external fixation pins for clinical application

Villatte G, Massard C, Descamps S, Sibaud Y, Forestier C, Awitor KO

International Journal of Nanomedicine 2015, 10:3367-3375

Published Date: 6 May 2015

Water-soluble l-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma

Liang SY, Zhou Q, Wang M, Zhu YH, Wu QZ, Yang XL

International Journal of Nanomedicine 2015, 10:2325-2333

Published Date: 23 March 2015