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Tuning the surface microstructure of titanate coatings on titanium implants for enhancing bioactivity of implants
Authors Wang H, Lai Y, Zheng R, Bian Y, Zhang K, Lin C
Received 17 October 2014
Accepted for publication 3 February 2015
Published 8 June 2015 Volume 2015:10(1) Pages 3887—3896
DOI https://doi.org/10.2147/IJN.S75999
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 6
Editor who approved publication: Dr Lei Yang
Hui Wang,1,2 Yue-Kun Lai,1 Ru-Yue Zheng,1 Ye Bian,1 Ke-Qin Zhang,1 Chang-Jian Lin2
1National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, 2State Key Laboratory for Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, People’s Republic of China
Abstract: Biological performance of artificial implant materials is closely related to their surface characteristics, such as microtopography, and composition. Therefore, convenient fabrication of artificial implant materials with a cell-friendly surface structure and suitable composition was of great significance for current tissue engineering. In this work, titanate materials with a nanotubular structure were successfully fabricated through a simple chemical treatment. Immersion test in a simulated body fluid and in vitro cell culture were used to evaluate the biological performance of the treated samples. The results demonstrate that the titanate layer with a nanotubular structure on Ti substrates can promote the apatite-inducing ability remarkably and greatly enhance cellular responses. This highlights the potential of such titanate biomaterials with the special nanoscale structure and effective surface composition for biomedical applications such as bone implants.
Keywords: nanotubes structure, bone-like apatite, cell culture, biological performance
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