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Tumor-Associated Macrophages (TAMs): A Critical Activator In Ovarian Cancer Metastasis

Authors Yin M, Shen J, Yu S, Fei J, Zhu X, Zhao J, Zhai L, Sadhukhan A, Zhou J

Received 20 May 2019

Accepted for publication 24 September 2019

Published 21 October 2019 Volume 2019:12 Pages 8687—8699

DOI https://doi.org/10.2147/OTT.S216355

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Aruna Narula

Peer reviewer comments 2

Editor who approved publication: Dr XuYu Yang


Meichen Yin, Jiayu Shen, Shuqian Yu, Jing Fei, Xiaoqing Zhu, Jiayao Zhao, Lingyun Zhai, Annapurna Sadhukhan, Jianwei Zhou

Department of Gynecology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China

Correspondence: Jianwei Zhou
Department of Gynecology, The Second Affiliated Hospital of Zhejiang University School of Medicine, No 88, Jiefang Road, Shangcheng District, Hangzhou, Zhejiang 310002, People’s Republic of China
Email 2195045@zju.edu.cn

Abstract: Tumor-associated macrophages (TAMs) that appear in every stage of cancer progression are usually tumor-promoting cells and are present abundantly in the tumor-associated microenvironment. In ovarian cancer, the overall and intratumoral M1/M2 ratio is a relatively efficient TAM parameter for predicting the prognosis of patients, especially for serous tissue type cancer. TAMs exhibit immunological checkpoint modulators, such as the B7 family and programmed death-ligand 1 (PD-L1), and play a key role in the development, metastasis and invasion of ovarian cancer, but the underlying mechanism is barely understood. Ovarian cancer is a severe gynecological malignancy with high mortality. Ovarian cancer-associated death can primarily be attributed to cancer metastasis. The majority of patients are diagnosed with wide dissemination in the peritoneum and omentum, limiting the effectiveness of surgery and chemotherapy. In addition, unlike other well-documented cancers, metastasis through vasculature is not a usual dissemination pathway in ovarian cancer. This review sheds light on TAMs and the main process and mechanism of ovarian cancer metastasis.

Keywords: ovarian cancer, tumor associated macrophages, classical activated macrophage, alternative activated macrophage, transcoelomic metastasis, hematogenous metastasis

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