Back to Journals » International Journal of Nanomedicine » Volume 2 » Issue 3

Tumor angiogenic endothelial cell targeting by a novel integrin-targeted nanoparticle

Authors Jianwu Xie, Zhimin Shen, King CP Li, Narasimhan Danthi

Published 15 October 2007 Volume 2007:2(3) Pages 479—485

Jianwu Xie1, Zhimin Shen2, King CP Li1,3, Narasimhan Danthi1

1Molecular Imaging Laboratory, Clinical Center and 2Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA; 3Department of Radiology, The Methodist Hospital, Houston, TX, USA

Abstract: Angiogenesis is an important process in cancer growth and metastasis. During the tumor angiogenic process, endothelial cells express various cell surface receptors which can be utilized for molecular imaging and targeted drug delivery. One such protein receptor of interest is the integrin αvβ3. Our group is involved in the development of molecular imaging probes and drug delivery systems targeting αvβ3. Based on extensive lead optimization study with the integrin antagonist compounds, we have developed a new generation of integrin αvβ3 compound (IA) which has superior binding affinity to αvβ3. Utilizing this IA as a targeting agent, we have developed a novel integrin-targeted nanoparticle (ITNP) system for targeted drug delivery and imaging of cancer angiogenesis. When multiple copies of the IA were conjugated onto the nanoparticle surface, strong and selective binding to the integrin αvβ3 was observed. These ITNPs also were rapidly taken up by cells that express αvβ3. The ITNPs accumulated in the angiogenic vessels, after systemic administration in a murine squamous cell carcinoma model. This novel intergrin targeted ITNP platform will likely have an application in targeted delivery of drugs and genes in vivo and can also be used for molecular imaging.

Keywords: targeted nanoparticle, integrin αvβ3, cancer, angiogenesis

Download Article [PDF] 

Readers of this article also read:

Antibody-conjugated, dual-modal, near-infrared fluorescent iron oxide nanoparticles for antiamyloidgenic activity and specific detection of amyloid-β fibrils

Skaat H, Corem-Slakmon E, Grinberg I, Last D, Goez D, Mardor Y, Margel S

International Journal of Nanomedicine 2013, 8:4063-4076

Published Date: 29 October 2013

Squamous cell papilloma of the conjunctiva due to human papillomavirus (HPV): presentation of two cases and review of literature

Kalogeropoulos C, Koumpoulis I, Papadiotis E, Zioga A, Gkrepi K, Pappa C, Paschides C, Malamou-Mitsi V, Aspiotis M

Clinical Ophthalmology 2012, 6:1553-1561

Published Date: 24 September 2012

Self-assembled supramolecular nano vesicles for safe and highly efficient gene delivery to solid tumors

Li W, Li H, Li J, Wang H, Zhao H, Zhang L, Xia Y, Ye Z, Gao J, Dai J, Wang H, Guo Y

International Journal of Nanomedicine 2012, 7:4661-4677

Published Date: 22 August 2012

Development of oral immunomodulatory agents in the management of multiple sclerosis

Nicholas R, Giannetti P, Alsanousi A, Friede T, Muraro PA

Drug Design, Development and Therapy 2011, 5:255-274

Published Date: 10 May 2011

Association of adiponectin levels and insulin demand in critically ill patients

Andreas Hillenbrand, Manfred Weiss, Uwe Knippschild, et al

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2011, 4:45-51

Published Date: 26 January 2011

Biodistribution studies of protein cage nanoparticles demonstrate broad tissue distribution and rapid clearance in vivo

Coleen R Kaiser, Michelle L Flenniken, Eric Gillitzer, Ann L Harmsen, Allen G Harmsen

International Journal of Nanomedicine 2007, 2:715-733

Published Date: 15 January 2008

VivaGel™ (SPL7013 Gel): A candidate dendrimer - microbicide for the prevention of HIV and HSV infection

Richard Rupp, Susan L Rosenthal, Lawrence R Stanberry

International Journal of Nanomedicine 2007, 2:561-566

Published Date: 15 January 2008

Triggered release of ciprofloxacin from nanostructured agglomerated vesicles

Rohan Bhavane, Efstathios Karathanasis, Ananth V Annapragada

International Journal of Nanomedicine 2007, 2:407-418

Published Date: 15 October 2007

Pi-Pi complexation of bupivacaine and analogues with aromatic receptors: Implications for overdose remediation

Evon Powell, Y-H Lee, Richard Partch, Donn Dennis, Timothy Morey, Manoj Varshney

International Journal of Nanomedicine 2007, 2:449-459

Published Date: 15 October 2007