Back to Journals » Clinical Ophthalmology » Volume 4

Trimetazidine for prevention of induced ischemia and reperfusion of guinea pig retina

Authors T Demir, B Turgut, I Ozercan, et al

Published 24 December 2009 Volume 2010:4 Pages 21—26

DOI https://doi.org/10.2147/OPTH.S8409

Review by Single-blind

Peer reviewer comments 4

T Demir1, B Turgut1, I Ozercan2, FC Gul1, N Ilhan3, U Celiker1

1Department of Ophthalmology, 2Department of Pathology, 3Department of Biochemistry, Fırat University School of Medicine, Elazig, Turkey

Objective: Trimetazidine (TMZ) has been used to protect against ischemia/reperfusion (I/R) injury of many tissues. We aimed to evaluate the effect of TMZ during retinal I/R in a guinea pig model.

Study design/patients and methods: An experimental study in retinal I/R. Three groups of five guinea pigs were studied to include a control, placebo, and drug test groups. Prior to the application of 90 minutes of high intraocular pressure (IOP) to induce retinal ischemia followed by 24 hours of reperfusion, we applied intraperitoneal saline to the placebo group and 3 mg/kg of TMZ for the drug test group and repeated the injections at intervals of six hours for four cycles. Both eyes of the animals were enucleated at the end of the reperfusion period. Biochemical assay and histopathologic evaluation was performed on one randomly selected eye of each animal. The level of retinal-free malondialdehyde (MDA) and retinal layer thicknesses were determined and comparisons were then made with the control group.

Results: The mean free MDA level increased in the placebo group (P = 0.006) but not in the drug group (P > 0.05). We observed polymorphonucleated leukocyte infiltration, retinal edema and hydropic degeneration in the retina of the placebo group. However, significant histopathologic change was not observed in specimens of the drug group.

Conclusions: This study suggests TMZ has a beneficial effect on retinal lipid peroxidation and histopathologic changes due to I/R injury.

Keywords: ischemia/reperfusion, retina, trimetazidine

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 

 

Other articles by this author:

Topical infliximab for the suppression of wound healing following experimental glaucoma filtration surgery

Turgut B, Eren K, Akın MM, Demir T, Kobat S

Drug Design, Development and Therapy 2014, 8:421-429

Published Date: 2 May 2014

Impact of ghrelin on vitreous cytokine levels in an experimental uveitis model

Turgut B, Gul FC, Dagli F, Ilhan N, Ozgen M

Drug Design, Development and Therapy 2013, 7:19-24

Published Date: 9 January 2013

Serum erythropoietin levels in patients with central serous chorioretinopathy

Burak Turgut, Nevin Ilhan, Fatma Yayla Uyar, et al

Eye and Brain 2010, 2:77-81

Published Date: 9 June 2010

The causes of serous macular detachment excluding central serous chorioretinopathy

Burak Turgut, Fatih Cem Gul, Tamer Demir, et al

Clinical Optometry 2010, 2:51-54

Published Date: 1 June 2010

An atypical case of optic disk drusen with nerve fiber layer thickening

Burak Turgut, Mehmet Kaan Kaya, Tamer Demir

Eye and Brain 2010, 2:67-71

Published Date: 28 May 2010

Levels of circulating homocysteine, vitamin B6, vitamin B12, and folate in different types of open-angle glaucoma

Burak Turgut, Murat Kaya, Sermal Arslan, et al

Clinical Interventions in Aging 2010, 5:133-139

Published Date: 23 April 2010

Atypical presentation of frosted branch angiitis from Turkey: a case report

Burak Turgut, Mehmet Kaan Kaya, Tamer Demir, et al

Clinical Optometry 2010, 2:39-41

Published Date: 20 April 2010

Spontaneous corneal perforation in a patient with lamellar ichthyosis and dry eye

Burak Turgut, Orhan Aydemir, Murat Kaya, et al

Clinical Ophthalmology 2009, 3:611-613

Published Date: 4 November 2009

Readers of this article also read:

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010