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Triglycerides and Total Cholesterol Concentrations in Association with Hyperuricemia in Chinese Adults in Qingdao, China

Authors Cui N, Cui J, Sun J, Xu X, Aslam B, Bai L, Li D, Wu D, Ma Z, Gu H, Baloch Z

Received 22 December 2019

Accepted for publication 13 February 2020

Published 2 March 2020 Volume 2020:13 Pages 165—173


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Marco Carotenuto

Nan Cui,1 Jing Cui,2 Jianping Sun,2 Xinping Xu,1 Bilal Aslam,3,4 Lan Bai,1 Decheng Li,1 Di Wu,1 Zhongren Ma,3 Hai Gu,1 Zulqarnain Baloch3

1Research Center for Health Policy and Management, Nanjing University, Nanjing, People’s Republic of China; 2Qingdao Centers for Disease Control and Prevention, Qingdao Institute for Preventive Medicine, Qingdao, People’s Republic of China; 3Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, People’s Republic of China; 4Department of Microbiology, Government College University Faisalabad, Faisalabad, Punjab, Pakistan

Correspondence: Hai Gu
Research Center for Health Policy and Management, Nanjing University, 101 Longmian Avenue, Jiangning District, Nanjing 210093, People’s Republic of China
Tel/Fax +8613687616923

Zulqarnain Baloch
Biomedical Research Center, Northwest Minzu University, Minying Road, Lanzhou 730030, People’s Republic of China
Tel +86-18344564625

Objective: To assess the association between triglycerides (TG), total cholesterol (TC) and hyperuricemia (HUA) in the general Chinese population.
Methods: A population-based cross-sectional survey included 9680 participants aged 35– 74 years in 2006 and 2009 in Qingdao, China. TG, TC and uric acid (UA) were measured. The logistic regression model was performed to estimate the association between TG, TC, and HUA with an odds ratio (OR) and 95% confidence intervals (CI). Meanwhile, age stratification analysis (< 55 years group and ≥ 55 years group) was performed to evaluate whether age potentially affects the association between TG, TC and HUA using multivariable logistic regression.
Results: Higher TG and TC showed significantly increased HUA prevalence in both men and women (Ptrend all < 0.05). Multivariate logistic regression indicated that borderline high TG (OR: 1.68, 95% CI: 1.31, 2.15 and HTG (OR: 2.98, 95% CI: 2.39, 3.72) indicated increased risk for HUA in men, and borderline high TG (OR: 2.09; 95% CI: 1.68,2.62); HTG (OR: 3.62; 95% CI: 2.90,4.51), borderline high TC (OR: 2.09, 95% CI: 1.68, 2.62) and HTC (OR: 3.62, 95% CI: 2.90, 4.51) showed significant association with HUA in women after adjusted age, school years, marital status, geographic division, personal monthly income, BMI and HDL-C. Age stratification analyses demonstrated that the association between TG and HUA was stronger in males aged ≥ 55 years and female aged < 55 years, and the association between TC and HUA was stronger in both gender aged < 55 years.
Conclusion: This large cross-sectional study focusing on the association between single indictor of blood lipid as exposure and HUA as outcome on the east coast of China for the first time. From a sample of Chinese adults, this study demonstrated that elevated TG in men and women and TC in women were associated with increased HUA prevalence.

Keywords: triglycerides, total cholesterol, hyperuricemia, Qingdao, Chinese population

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