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Treatment with sodium hyaluronate eye drops in a patient who had early-onset bleb leakage after trabeculectomy with mitomycin C

Authors Sagara H, Sekiryu T, Noji H, Ogasawara M, Imaizumi K, Yago K

Received 28 August 2015

Accepted for publication 15 October 2015

Published 27 November 2015 Volume 2015:8 Pages 301—304

DOI https://doi.org/10.2147/IMCRJ.S95334

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Yang Liu

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Hideto Sagara,1,2 Tetsuju Sekiryu,2 Hiroki Noji,2 Masashi Ogasawara,2 Kimihiro Imaizumi,2 Keiko Yago3

1The Marui Eye Clinic, Minamisoma, 2Department of Ophthalmology, School of Medicine, Fukushima Medical University. 3Northern Fukushima Medical Center, Fukushima, Japan

Abstract: We present the case of a 47-year-old man who had bilateral proliferative diabetic retinopathy and neovascular glaucoma. Schirmer I test revealed tear secretions of 5 mm and 3 mm in the right and left eyes, respectively. Tear breakup times in the right and left eyes were 7 and 8 seconds, respectively. The ocular surface staining in both eyes was scored as Grade 1 as per the Oxford scheme. Retinal photocoagulation was performed for correction of the proliferative diabetic retinopathy and rubeosis iridis, which resolved with treatment. However, the intraocular pressure in the left eye could not be adequately controlled. Therefore, trabeculectomy with mitomycin C using limbal-based conjunctival flap was performed. Three hours after the surgery, the patient developed a large and diffuse filtering bleb, but no leakage occurred from the conjunctival scar. However, on the first postoperative day, leakage was noted and the conjunctiva was at the leakage point. The leakage resolved transiently, but recurred the next day. Severe keratoconjunctival epithelial failure was detected, and the patient was administrated 0.1% sodium hyaluronate eye drops six times daily. The epithelial failure improved, and many microcysts were detected on the bleb surface where the epithelial failure improved. The leakage resolved 2 days after initiation of the sodium hyaluronate eye drops. The microcysts disappeared and the bleb surface became smooth 1 month later.

Keywords: trabeculectomy, bleb, bleb leak, microcyst, sodium hyaluronate

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