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Treatment satisfaction in cystic fibrosis: early patient experience with tobramycin inhalation powder

Authors Greenberg J, Palmer JB, Chan WW, Correia CE, Whalley D, Shannon P, Sawicki GS

Received 10 December 2015

Accepted for publication 3 June 2016

Published 26 October 2016 Volume 2016:10 Pages 2163—2169

DOI https://doi.org/10.2147/PPA.S102234

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 2

Editor who approved publication: Dr Johnny Chen

Jonathan Greenberg,1 Jacqueline B Palmer,2 Wing W Chan,2 Catherine E Correia,1 Diane Whalley,3 Paul Shannon,3 Gregory S Sawicki1

1Division of Respiratory Diseases, Boston Children’s Hospital, Boston, MA, 2Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; 3RTI Health Solutions, Manchester, UK

Background: This study assessed treatment satisfaction of cystic fibrosis (CF) patients in a routine clinical setting for tobramycin inhalation powder (TIP), the first dry powder–inhaled antibiotic for Pseudomonas aeruginosa infection.
Methods: CF patients aged 6 years or older treated with at least one cycle of TIP completed a web survey on experience with TIP, including the Treatment Satisfaction Questionnaire for Medication (TSQM). Regression analysis determined the factors associated with TSQM global satisfaction.
Results: Eighty patients (mean age ± standard deviation: 24.4±9.4 years; 57.5% female; mean forced expiratory volume in 1 second ± standard deviation: 67.1%±27.3% predicted) completed the survey. The majority expressed satisfaction with TIP’s administration time (100%), time to clean (97.1%), portability (97.1%), and ease of use (94.3%). Effectiveness was significantly associated with TSQM global satisfaction (regression R-squared: 0.54).
Conclusion: Patient preferences for TIP were based on administration time and ease of use. Global satisfaction was related to greater patient-perceived effectiveness.

Keywords: cystic fibrosis, patient satisfaction, tobramycin, dry powder inhalers

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