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Treatment Outcomes and Predictors of Recovery from Severe Acute Malnutrition Among Children Aged 6–59 Months Attending an Outpatient Therapeutic Program in Wenago District, Southern Ethiopia

Authors Simachew Y, Zerfu T, Alemu W

Received 29 January 2020

Accepted for publication 26 August 2020

Published 24 September 2020 Volume 2020:12 Pages 189—200

DOI https://doi.org/10.2147/NDS.S245070

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Chandrika Piyathilake

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Video abstract presented by Yilkal Simachew.

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Yilkal Simachew,1 Taddese Zerfu,2 Wagaye Alemu3

1School of Public Health, College of Medicine and Health Science, Hawassa University, Hawassa, Ethiopia; 2Department of Nutrition, College of Medicine and Health Science, Dilla University, Dilla, Ethiopia; 3Department of Public Health, College of Medicine and Health Science, Dilla University, Dilla, Ethiopia

Correspondence: Yilkal Simachew
School of Public Health, College of Medicine and Health Science, Hawassa University, P.O. Box: 1560, Hawassa, Ethiopia
Tel +251 941050775
Fax +251 462122122
Email [email protected]

Background: The outpatient therapeutic program (OTP) of children with severe acute malnutrition (SAM) brought the treatment approach closer to the community. In spite of the high coverage and accessibility, a low recovery rate of OTP is often reported. Thus, the aim of this study was to assess the treatment outcomes and identify predictors of recovery among children aged 6– 59 months with SAM enrolled to OTP in Wenago district, Southern Ethiopia.
Methods: A facility-based cross-sectional study was conducted by assessing health records and interviewing mothers of 554 children, who were treated between July 2017 and February 2018. A single stage cluster sampling was used to enroll the study participants. The data were coded and entered into EpiData version 3.1, and analyzed by SPSS version 20. Binary logistic regression was used to identify predictors of recovery. All statistical tests in this study were declared significant at P< 0.05.
Results: The recovery, average weight gain rate and length of stay were 70.4%, 3.9 g/kg/day and 6.67 weeks, respectively. The adjusted odds ratios to recovery of children who were treated with amoxicillin, born from a mother whose age at first marriage was > 18 years, from a food secured household and had access to safe water sources were (AOR=3.97, 2.75, 3.21 and 2.96; 95% CI= 2.32, 6.78, 1.54, 4.93, 1.86, 5.52, and 1.61, 5.45), respectively. Conversely, children from households with three under-5 year olds had a 86% (AOR=0.14; 95% CI 0.05, 0.38) less risk of recovery as compared to children from households with only one under-5-year-old child.
Conclusion: The recovery rate, average daily weight gain and length of stay in the program were not within the acceptable sphere standards. Provision of amoxicillin, numbers of under-5-year-old children in the house, maternal age at first marriage, a source of water and food security status were independently associated with recovery from SAM under OTP.

Keywords: outpatient therapeutic program, treatment outcome, severe acute malnutrition, Wenago district

Introduction

Malnutrition is more than a lack of food, it is a combination of factors: insufficient protein, energy and micronutrients, frequent infections or disease, poor care and feeding practices, inadequate health services, and poor water and sanitation.1 It encompasses both overnutrition associated with overweight and obesity, and undernutrition. It remains as the leading common cause of morbidity and mortality among children throughout the world.2 Undernutrition encompasses different nutritional disorders, including severe acute malnutrition (wasting and bilateral pitting edema), stunting, underweight, and micronutrient deficiency disorder.3

According to the World Health Organization (WHO) definition, severe acute malnutrition (SAM) is a weight for height ratio (WFH) of less than −3 standard deviations (SD) below the median reference population or weight for height ratio of below 70% or presence of nutritional edema.4 Children suffering from SAM have a 5–20 times greater risk of death than well-nourished children.5

In 2016, nearly (7.7%) 52 million of the world’s under-5-years-old children had acute malnutrition, and 17 million had SAM.6 More than two thirds of all acutely malnourished under-5-years-old children live in Asia and more than one quarter lives in Africa. Ethiopia is one of the countries with the highest under-5 child mortality rate, with malnutrition underlying to 51% of all children's deaths.7 The 2016 Ethiopian Demographic and Health Survey (EDHS) reported 10% of children 6–59 months of age are wasted (acute malnutrition). It has been estimated that approximately 3% of these children have SAM. According to Southern Nations Nationalities and Peoples’ Region (SNNPR) 2016 annual report the incidence rate of SAM was 14 SAM cases per 1000 under-5 children and the Gedeo zone ranked the highest with 32 SAM cases per 1000 under-5 population. In a similar report, the incidence rate of SAM in the study area (Wenago district) was 48 SAM cases per 1,000 under-5 population.8

Previously, children with SAM were managed in a health facility through inpatient care.9 However this approach posed many challenges to effective treatment for both health systems and patients, some of the challenges were low coverage and impact, costliness, heavy staff work load, overcrowding, cross infections, and high mortality rate.5 To reduce those limitations, community-based management of acute malnutrition (CMAM) was endorsed with a joint statement of WHO and UNICEF in 2007.4 This advance decentralized management system to the community-based approach. Community outreach, outpatient management of SAM children without medical complications (OTP), inpatient management of SAM children with medical complications and the program addressing moderate acute malnutrition (MAM) were designed as components of CMAM.

The OTP offers service to severely malnourished children age 6–59 months. The admission criterion for OTP according to the protocol for management of SAM is Mid Upper Arm Circumference (MUAC) of less than 110mm or WFH of less than 70% or presence of bilateral pitting edema. Only children who have appetite with Plumpy’Nut® and those who do not have medical complications are eligible for the OTP.9 This group of children represents over 90% of all SAM cases.10

However, children presenting with medical complications will not be admitted to OTP, rather they are referred to the therapeutic feeding unit (TFU). The TFU is provided in health centers and hospitals to manage severely malnourished children with medical complications as inpatients until their illness is stabilized.4,9

The OTP is provided by health extension workers at the health posts. The service is provided daily for new cases and one OTP day in a week is scheduled for follow up of enrolled cases. The children undergo an appetite test and receive ready to use therapeutic feeding (RUTF) and routine medications (Vitamin A, folic acid, antibiotics, deworming) for admission at home. They return weekly to the outpatient care site until they are discharged.9

Children admitted to OTP are discharged by their respective admission criteria. Children admitted with wasting get discharged from the OTP when they gain 15% of weight at admission. Unlike wasting, children admitted with edema are discharged from the OTP after their edema has disappeared for 2 consecutive weeks.3,9 The treatment outcomes (recovery, death, default, weight gain, and length of stay) compared with international sphere standard to evaluate the program effectiveness.9 The reference values have been developed by sphere project and they give an indication of what might be considered acceptable and alarming (Table 1).4

Table 1 The Sphere Standard Reference Value for the Main Indicators of OTP

Good treatment outcome under OTP has social, psychological, cultural and economic implications.11 Despite this fact previous studies have concentrated on the factors that are associated with treatment outcomes like socio-demographic and anthropometric characteristics of children, medical-related factors, adherence to treatment protocol, co-morbidity at admission and during follow up. However other equally important factors like maternal/caregiver-related factors, household and environmental factors have been given little attention.12 In addition, even though Wenago district has a large number of children with SAM and admission to OTP, there is no published study conducted to show the program performance and factors associated with recovery. Therefore, this study aimed to measure the treatment outcomes and identify factors associated with recovery among SAM children aged 6–59 months that were admitted to OTP in Wenago district, Southern Ethiopia.

Materials and Methods

Study Setting and Period

The study was conducted in Wenago district Gedeo zone SNNP region, which is located 377 km from Addis Ababa (the capital city of Ethiopia), 102 km from Hawassa (Regional city) and 14 km from Dilla (capital of Gedeo zone) at (N 6° 20ʹ and E 38° 19ʹ). The district is one of the most densely populated areas in the country.13 The district has 21 kebeles (4 urban and 17 rural kebele) and a total of 26 health facilities (6 health centers and 20 health posts), where only health posts provide OTP service. The common health problems in this district are malaria, diarrhea, under-5 pneumonia and malnutrition.8

The study was conducted between March 10 and May 20, 2018.

Study Design

A facility-based cross-sectional study was conducted.

Source and Study Population

All 6–59 months of age child-mothers/caregivers pairs, who were treated in the OTP at health facilities of Wenago district, were the source population.

All 6–59 months of age child-mothers/caregivers pairs with SAM who were treated in the selected OTP sites between July 1, 2017 and February 30, 2018 in Wenago district, were the study population.

Inclusion and Exclusion Criteria

All 6–59 months of age child-mother/caretaker pairs admitted to OTP between July 1, 2017 and February 30, 2018, and permanent residents of the Wenago district (who had lived there for at least 6 months) were included.

Children who transferred from the inpatient therapeutic care, children who were known to be suffering from other known chronic illnesses (TB, HIV/AIDS) and children with incomplete records on anthropometric measurements (weight, MUAC), socio-demographic data (age, gender), admission criteria and treatment outcome were excluded from the study in order to make clear comparisons and proper interpretations of the result.

Sample Size Determination and Sampling Procedure

Sample Size

Sample Size Determination for Treatment Outcome of OTP

The minimum sample size required for treatment outcome of OTP was calculated by using a single population proportion formula, using the following assumptions

n= minimum sample size

P= the recovery rate of children treated under OTP 67.7% taken from a study conducted in Kamba district, South west Ethiopia.14

d= margin of error to be tolerated (5%)

By considering 10% non response rate, and multiplying by 1.5 design effect the final sample size becomes 554.

Sample Size Determination for Factors Associated with Recovery

The sample size determination for the second objective, that is identifying factors associated with recovery in OTP, wascalculated based on a double population proportion formula by using Epi info version 7 stat calc programs (Table 2).

Table 2 Sample Size Determination for Factors Associated with Recovery

Since the calculated sample size for the second objective was less than the sample size calculated for the first objective, 554 was taken as the final sample.

Sampling Procedure

Wenago district has a total of six health centers and 20 health posts, with only health posts providing OTP services. Homogeneity among the 20 health posts was assumed in terms of staff, use of same protocol for management, with all staffs taking training on SAM management. In addition population around health posts assumed nearly homogeneous. With this assumption, 10 health posts were selected randomly. From the selected health posts, eligible children with SAM were identified from OTP cards for those admitted from July 1, 2017 to February 30, 2018. After this, whether the mother/caregiver of an eligible child was a permanent resident of Wenago district was checked and a sampling frame was prepared for each OTP site. Finally, from the selected health posts a total of 554 eligible study subjects (child and mother pairs) were identified. The selection of the eligible study subjects is shown in Figure 1.

Figure 1 Schematic presentation of sampling procedure.

Study Variables

The “dependent variable” was the treatment outcome from OTP (recovered/not recovered).

The “independent variables” included the socio-demographic and admission characteristics of each child (age, sex, breast-feeding during treatment, referral system, admission status), the clinical characteristics of the children on admission (type of nutritional diagnosis, provision of routine medication at admission, co-morbidities on admission, appetite test on admission), the socio-demographic and economic characteristics of mothers/caregivers of the children (maternal age, maternal education, residence, marital status, mother’s occupation, family size, number of under-5 children in the house, maternal age at first marriage, wealth index, maternal perception about child feeding, and distance of health institution from the residence), and environmental- and sanitation-related factors (source of water, water storage, availability of latrine, method of waste disposal, household food security status).

Operational Definitions

The “treatment outcome” was defined as recovered or not recovered from SAM management at OTP in this study.

“Recovered” was defined as a gain of 15% of weight at admission for wasting children and resolution of edema for 2 consecutive weeks for kwashiorkor children,9 while “not recovered” was defined as children discharged from OTP with outcome other than recovery in this study (death, default, non-responder, medical transfer and falsely recovered).15

“Non-responder” was defined as a patient that failed to reach the discharge criteria after 8 weeks of treatment in the program.9

A “defaulter” was defined as a child who was absent for two consecutive follow-up visits from the OTP and confirmed by home visit.9

“Weight gain” is the average weight gain (in grams) for every kg of body weight of the child per day. Weight gain calculation was conducted for recovered children in the marasmus categories, with a formula of

= (Discharge weight in gram – Admission weight in gram)/ (Admission weight in kg)/ (Number of days in program).9

The “average length of stay” was calculated by adding the total number of days that each child stays in the OTP until cured, and dividing this by the number of children cured for a specific month.9

Maternal Perception of Child Feeding

Maternal perception about child feeding was assessed using Likert scale questions. At the end, mothers who scored above mean on all questions were labeled as having a positive perception about child feeding and those scoring below the mean were labeled as having a negative perception.

Household Food Security Status

Household food security status was labeled as a food secured household if the respondents replied no to all eight standard questions of the household insecure experience scale survey tool (HHFIES), and a food insecure household if the respondent’s replied yes to at least one question.16

Data Collection Procedure and Tool

The data were collected using two approaches, review of the child OTP card (using a structured data abstraction form which were adopted from the Federal Minister of Health)9 and a structured interviewer administered questionnaire to collect data from mothers/caregivers of selected children.

The OTP card includes information like the socio-demographic characteristics of a child, including age, sex, patient baseline information, including date of admission, type of admission, admission anthropometry, and routine admission medication; follow up information on weight, MUAC, edema, appetite test, treatment outcome, and date outcome were ascertained. Baseline admission characteristics in terms of medications received and breast feeding. All these data were collected using the structured data abstraction forms. While maternal- and environmental-related factors of identifying children were collected using the structured questionnaire, after tracing mothers/caregivers of the identified children at their home. Data were collected using 10 diploma nurses and supervised by two supervisors with a bachelor degree in public health.

Data Analysis

The collected data were entered into EpiData software version 3.1 and exported to statistical package for social science (SPSS) version 20 for analysis. First, descriptive analysis was carried out for each of the variables. The association between dependent and independent variables was assessed and its strength presented using odd ratios and 95% confidence interval. Using binary logistic regression the crude relationship between each predictor variables and outcome variable was assessed, and those independent variables with a P-value less than 0.25 was considered as a candidate variable for multivariate logistic regression. Finally, a P-value less than 0.05 was declared statistically significant.

Data Quality Control

The questionnaire was first prepared in English then translated into Gedeofa and back translatedinto English by independent translators to check its consistency. Consensus on the compatibility of forward and backward translation was assured before the actual data collection activities.

Data collectors and supervisors were trained for 2 days by the principal investigator before the actual study commenced on the objectives of the study, how to extract data from the OTP card, how to interview, how to fill in the questionnaire and how to handle the questions asked by the study subjects. As part of the training, the data collection tool was pre-tested in 5% of the sample size at Dilla zuria wereda (adjacent to the study area) before the actual data collection time to check a data extraction form, address the study variables, as well to check the extent at which the questions were understood by the interviewee and to identify areas for modification and correction. Based on the pretest some chronological arrangements were made and two questions were also added to the questionnaire. The principal investigator and supervisors checked the completeness and consistency of collecting data on a daily basis and necessary feedback was given to the data collectors.

Before data entry, in order to make data processing easier, a code was given to each interviewer, and data entry format was prepared in EpiData software according to a pre-coded questionnaire. To reduce some errors during data entry, a check file was developed (to detect and refuse some data entry mistakes). Before conducting analysis in SPSS software, data cleaning was done to check for the presence of outliers, to check for consistency and to verify the skip pattern was followed. In addition, exploratory data analysis was carried out to check the levels of missing values and the presence of multi co-linearity.

Ethical Considerations

A letter of ethical clearance was obtained from Dilla University, College of Medicine and Health Science institution review board; which was then submitted to Gedeo zone health department. After having a formal letter of permission from Gedeo zone health department, the letter was submitted to Wenago district health office, and then a cooperation letter was obtained to collect data from selected health posts. After detailed explanation of the main purpose of the study, a written consent form (using their fingerprint) was obtained from mothers/caregivers of children to agree to the collection of data from them. The finger print consent process was approved by the Dilla University institutional Review board and this study was done in accordance with the declaration of Helsinki.

Results

The study included records of 554 children who had been managed for severe acute malnutrition under 10 selected OTP sites from July 1, 2017 to February 30, 2018, and their caregivers, which give 100% response rate.

Socio-Demographic and Admission Characteristics of the Children

Among the children included in the study, a majority or 291 (52.5%) were females by gender and under 2 years (323, 58.3%) by age category. The median age of children at admission was 24 months with an inter quartile range of 12 to 36 months. A sizable proportion of the children (205, 37%) were referred to OTP from the community health day (CHD) activities, followed by community volunteers 194 (35%), and self referral 155 (28%).

The health records of children whose data was assessed showed more than nine in ten (92.4%) of children were new admissions, while the rest (6.3%) and (1.3%) being readmissions and return after default, respectively. Most (482, 87%) of the children were admitted from rural areas taking a median time of 30 minutes’ walk to reach the health facility (Table 3).

Table 3 Socio-Demographic and Admission Characteristics of Children Admitted to OTP from Severe Acute Malnutrition in Wenago District, Southern Ethiopia 2018

Clinical Characteristics of Children Admitted to OTP

Three-quarters (420, 75.8%) of the children were admitted with wasting and the rest (134, 24.2%) with the presence of edema. Among the children who were admitted for presence of edema, more than three-quarters or 102 (76.3%) had grade Ι edema, followed by 29 (21.6%) had grade ΙΙ edema, and 3 (2.2%) had grade ΙΙΙ edema.

On admission more than half (309, 55.8%) of the children were on breast feeding. Amoxicillin (376, 67.9%) and vitamin-A (114, 20.6%) were the most often supplied medication; while folic acid was the least supplied (0.2%). All of the 554 (100%) children admitted passed the appetite test and 457 (96.4%) had a normal body temperature; but close to one in five 102 (18.4%) had fast breathing (Table 4).

Table 4 Clinical Characteristics of Children on Admission Under OTP from Severe Acute Malnutrition in Wenago District, Southern Ethiopia 2018

Socio-Demographic and Economic Characteristics of Mothers/Caregivers of Selected Children

The finding shows the median age of mothers/caregivers of children was 28 years with IQR of 25 to 31 years. The majority (529, 95.5%) of the participants were affiliated to the protestant faith. Mothers/caretakers from Gedeo ethnic group numbered 520 (93.9%) of them. Close to three quarters or 409 (73.8%) were illiterate.

Considering maternal family characteristics, more than three-quarters (421, 76%) of them were housewives and 519 (93.7%) were married. The median family size of the household was 5 (with IQR of 4.7–6.0). More than half of the households had at-least two or more under-5 children; 259 (46.8%) had two and 72 (13%) had three under-5 children. In the same way, slightly above half, 290 (52.3%) of the mothers/caregivers were married after 18 years of age, with a median age of 18 (IQR 16–19 years). Two-thirds (66.1%) of mothers had a positive perception toward appropriate child feeding practices. Socioeconomic status of the study population was assessed by wealth index and one-third (184, 33.2%) of the participants belonged to low socioeconomic status (Table 5).

Table 5 Socio-Demographic and Economic Characteristics of Mothers/Caregivers of Children in Outpatient Therapeutic Feeding Program in Wenago District, Southern Ethiopia 2018

Environmental- and Sanitation-Related Characteristics

The study shows almost all (530, 95.7%) of the participants had private latrines, but only 117 (22%) had a hand washing facility with the latrine. Similarly, more than three-quarters (417, 75.3%) had access to an improved water source, and 228 (41.2%) reported to treat drinking water before consumption. More than two-thirds (386, 69.7%) stored drinking water in plastic “jerricans” and the rest stored it in traditional clay pots. In addition, more than two-thirds (370, 66.8%) of respondents reported disposing of solid waste in the open field. More than half or 289 (52.2%) of the participant households were food secured, while the remaining 265 (47.8%) households were food insecure (Table 6).

Table 6 Environmental- and Sanitation-Related Characteristics of the Participants of Outpatient Therapeutic Feeding Program in Wenago District, Southern Ethiopia 2018

Treatment Outcomes

Of the total 554 children admitted to an outpatient therapeutic program, the recovery rate from severe acute malnutrition was 390 (70.4%) (Figure 2). The median recovery time from OTP was 7 weeks with IQR of 6–8 weeks. Half (195, 50%) of the children recovered from SAM at less than 7 weeks of duration. Among the wasting children who recovered from SAM had gained an average weight of 3.9 g/kg/day.

Figure 2 The treatment outcome of SAM children admitted to outpatient therapeutic program, Wenago district, Southern Ethiopia 2018.

Predictors of Recovery Among Children Admitted to OTP

During the initial bivariate analysis, referral system, distance, diagnosis at admission, provision of antibiotics, provision of vitamin-A, residence, maternal educational status, family size, number of under-5 children in the house, maternal age at first marriage, source of water, maternal perception on child feeding, wealth index, and household food security status had significant associations with recovery at 0.25 P-value (Table 7).

Table 7 Bivariate and Multivariate Analysis of Factors Associated with Recovery Among Children Aged 6–59 Months with Severe Acute Malnutrition Admitted to OTP at Wenago District, Southern Ethiopia 2018

But, applying the multivariate logistic regression: administration of antibiotics, the number of under-5 children in the house, maternal age at first marriage, a source of water, and household food security status remain in the final model predicting outcome of recovery from OTP at 0.05 P-value. Children provided with amoxicillin were 3.97 times more likely to recover from SAM than to those who were not given amoxicillin (AOR=3.97 at 95% CI: 2.32, 6.78). Children from households which had three under-5 children had 86% reduced odds of recovery as compared to children from households which had only one under-5 child (AOR=0.14 at 95% CI: 0.05, 0.38). The odds of recovery from OTP among children born from mothers whose age at first marriage was 18 years and above was 2.75 times higher than that of children born from mothers whose age at first marriage was below 18 years (AOR=2.75 at 95% CI: 1.54, 4.93). Children from households that had an improved water source for consumption had 2.96 times higher probability of recovery from SAM as compared to children from households that used unimproved water sources (AOR=2.96 at 95% CI: 1.61, 5.45). Families living in food secured households had a 3.21 times higher chance of their children recovering from SAM as compared to those families living in food insecure households (AOR=3.21 at 95% CI: 1.86, 5.52) (Table 7).

Discussion

Treatment Outcomes

The findings of this study revealed 390 (70.4%) SAM children admitted to OTP recovered. This indicates the recovery rate was lower than the international sphere standard which set the lower threshold at 75%.17 This finding is lower than findings from studies carried out in Shebedino district, southern Ethiopia (78.7%)18 and Bedawacho district with a recovery rate of 85%.19 This disparity might be because, in this study a child discharged as recovered without reaching discharge criteria was labeled as false recovery, while the above two studies did not assess false recovery. The low recovery rate may be explained by inadequate provision of routine medications and interrupted provision of RUTF.

In contrast, the recovery rate is higher than the study done in Tigray region with a recovery rate of 61.7% and Sidama zone with a recovery rate of 68.8%.11,20 This may be explained by the presence of a high default rate of 13.8% and 24.1% in the Tigray and Sidama studies, respectively.

The default rate of 55 (9.9%) is within the acceptable range of sphere standard (<15%).17 The low default rate may indicate that the mothers/caregivers in the study area were aware about the consequence of defaulting from OTP. The low default rate could also be linked with poor socioeconomic status of households, which force them to attend the OTP for plump nut in order to fulfill the basic needs of the household (to share with other under-5 children, or sell some of the RUTF to feed the whole family).

The average weight gain of children admitted with marasmus was 3.9 g/kg/day, which is far out of the acceptable range of international sphere standard.16 The finding was lower as compared to a report from Kamba district (5.76 g/kg/day) and Wolayita region (4.2 g/kg/day).14,15 The lower average weight gain below sphere standard and the above two studies might be explained by inadequate provision of routine medications and improper utilizations of RUTF.

The average length of stay of children with SAM in OTP was 6.67 weeks. This result is far outside of the acceptable minimum sphere standard, which is 4 weeks.17 This finding is in line with studies done in Enderta district, northern Ethiopia (6.28 weeks).12 The average length of stay could be increased above the acceptable range because 7.2% of the recovered children were allowed to stay in the program for longer than 8 weeks. However, those children should have been referred for inpatient treatment in a stabilizing center at their 8th week of stay in OTP, when they fail to reach the discharge criteria. Inadequate or partial provision of routine medications and the intention of caregivers to stay in the program for long periods to secure a supply of RUTF might also contribute to the delay of recovery from SAM.

Factors Associated with Recovery

Children given amoxicillin were 3.97 times more likely to recover from SAM than those who were not given amoxicillin. The finding was in line with the reports from OTP in Kamba, Tigray and Kenya.11,14,21 This can be explained by the following reasons; almost all children with SAM experience bacterial overgrowth in small bowel, this enteric bacteria frequently are the source of systemic infection by translocation across the bowel wall. This results in malabsorption of nutrients, diarrhea and poor appetite. So, even if they do not have clinical signs of infection, they have to treat blindly.9 By suppressing the bacterial growth in the small bowel it facilitates the recovery progress of children from SAM in OTP.

Children from mothers whose age at first marriage was 18 years and above had a better chance of recovery as compared to those who were from mothers whose age at first marriage was under 18 years. This result was in line with a report in Tigray.12 The explanation for this could be because early marriage had a negative impact over maternal health outcome, and this situation increases the likelihood of poor infant and child outcome.22 In addition, early married women are usually forced to end their education early and this reduces their employment participation and gives them less power and decision making within the household.23 All of those factors will affect the child caring practice of the mother and this might affect the treatment outcome/recovery of children with SAM.

Children from households that use improved water sources had a higher chance of recovery as compared to children from households that use unimproved water sources. This finding agrees with the studies done in South Wollo zone of Amhara region and Tahoua region, Southern Niger, their reports indicating that having improved water sources is independently associated with improved program outcomes.24,25 This could be because an unprotected water source enhances a child’s susceptibility to diarrheal and intestinal parasitic infection (hookworm), which in turn results in malabsorption of nutrients, poor appetite and anemia. Hence; a child who uses a protected water source is less vulnerable to diarrheal and intestinal parasitic infection, and hence more easily develops a high recovery rate as compared with a child using an unprotected water source.

Households with three under-5 children had an 86% reduced chance of recovery compared to households with only one under-5 child. It deduced that the birth spacing is one of the critical determinants of child recovery from SAM in OTP. This could be due to increased division of available resources in the household resulting in a nutritional shortfall and might force the presence of plump nut sharing among other healthy under-5 children. Mothers’ who have three children under 5-years of age may not properly take care of their children and also the household sanitation and hygienic conditions could be neglected while she is involved in income generating and reproductive works.

A family who lives in a food-secured household has a higher chance of having children recover from SAM as compared to their counterparts. Because SAM is a symptom of broader problems that affect a family rather than a disease in an individual.26 This can be explained because, even though RUTF provided as treatment for affected children, in food insecure households the actual amount of RUTF consumed by SAM children can be less than the amount provided due to sharing with other children in the household or use of RUTF as a commodity for meeting the household economies and food need, which endangers the child's recovery.

Conclusion

The findings of the study revealed that the recovery rate and the average weight gain were below sphere standard range, also the treatment duration (length of stay) was longer than the sphere recommendation. Factors like amoxicillin provision, maternal age at first marriage, a source of water, the number of under-5 children in the house and food security status are predictors of recovery of SAM children in OTP. Therefore, stakeholders like the federal minister of health should consider integrating OTP with agricultural extension programs and productive safety net programs (PSNP) in food insecure areas to improve the recovery of SAM treatment. Wenago district health office needs to strengthen health education for all family members about the benefits of healthy birth spacing and use of family planning methods. Wenago district gender office needs to educate the community to avoid the harmful practice of early marriage. Health centers should focus on creating the capacity of HEW on proper managements of SAM. For researchers, a prospective study should be conducted for better information by including other factors not included under this study, such as the effects of anemia and proper provision of treatment to the index child at home.

Abbreviations

CHD, community health day; CMAM, community-based management of acute malnutrition; EDHS, Ethiopian Demographic and Health Survey; EFY, Ethiopian Feasible Year; GDP, gross domestic product; HDA, health developmental army; HEWs, health extension workers; IQR, inter quartile range; MAM, moderate acute malnutrition; MUAC, mid upper arm circumference; OR, odds ratio; OTP, outpatient therapeutic program; PSNP, productive safety net program; RUTF, ready to use therapeutic feeding; SAM, severe acute malnutrition; SNNPR, South Nation Nationality People Region; SPSS, Statistical Package for Social Science; TFU, therapeutic feeding unit; UNICEF, United Nations Children’s Emergency Fund; WFH, weight for height; WHO, World Health Organization.

Acknowledgments

The authors would like to express their deepest acknowledgement to the NORAD project for their financial support to conduct this research. Furthermore, the authors would like to thank health extension workers of Wenago district for their full cooperation and vital assistance during data collection. Finally, the authors would like to thank all the data collectors, supervisors and research participants who took part in the study.

Disclosure

The authors report no conflicts of interest in this work.

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