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Treatment of systemic sclerosis: potential role for stem cell transplantation

Authors Xiong W, Derk C

Published 18 November 2009 Volume 2009:2 Pages 1—9

DOI https://doi.org/10.2147/SCCAA.S5282

Review by Single-blind

Peer reviewer comments 3

Wen Xiong, Chris T Derk

Division of Rheumatology, Thomas Jefferson University, Philadelphia, PA, 19107, USA

Abstract: Hematopoietic stem cell transplantation may “reset” the immune reconstitution and induce self tolerance of autoreactive lymphocytes, and has been explored in the treatments for systemic sclerosis. Phase I/II trials have shown a satisfactory risk benefit ratio. The true benefit will be identified by two ongoing prospective, randomized phase III trials. Multipotent mesenchymal stromal cells (MSCs) possess antiproliferative, anti-inflammatory, and immunosuppressive properties. The use of MSCs has showed successful responses in patients with severe steroid-resistant acute graft versus host disease in phase II trials, and may be a potentially promising option for patients with systemic sclerosis.

Keywords: scleroderma, systemic sclerosis, treatment, stem cells, transplant

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