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Translational and clinical perspectives on sphincter of Oddi dysfunction

Authors Kyanam Kabir Baig K, Wilcox CM

Received 15 October 2015

Accepted for publication 8 April 2016

Published 28 July 2016 Volume 2016:9 Pages 191—195

DOI https://doi.org/10.2147/CEG.S84018

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Yi Shen

Peer reviewer comments 2

Editor who approved publication: Professor Andreas M Kaiser


Kondal Rao Kyanam Kabir Baig,1,2 Charles Melbern Wilcox1

1Division of Gastroenterology and Hepatology, University of Alabama, 2Birmingham VA Medical Center, Birmingham, AL, USA

Abstract: Sphincter of Oddi dysfunction is a complex pathophysiologic entity that is associated with significant morbidity causing abdominal pain, nausea, and vomiting. The purpose of this review is to describe the anatomy and physiology of the sphincter of Oddi, to understand the pathologic mechanisms thought to be responsible for symptomatology, review recent major studies, explore endoscopic and pharmacologic therapies and their efficacy, and to explore future research avenues.

Keywords: SOD, abdominal pain, pancreatitis, sphincter dysfunction, abnormal liver tests, biliary dilation

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