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Tranexamic acid for the prevention and management of orthopedic surgical hemorrhage: current evidence

Authors Kim C, Park SS, Davey JR

Received 20 May 2015

Accepted for publication 22 July 2015

Published 25 August 2015 Volume 2015:6 Pages 239—244


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Hitesh Soni

Peer reviewer comments 2

Editor who approved publication: Dr Martin Bluth

Christopher Kim, Sam Si-Hyeong Park, J Roderick Davey

Division of Orthopedic Surgery, Toronto Western Hospital, Toronto, Ontario, Canada

Abstract: Total joint arthroplasty can be associated with major blood loss and require subsequent blood transfusions for postoperative anemia. Measures to effectively and safely decrease blood loss and reduce the need for blood transfusions would help improve patient safety and lower health care costs. A possible pharmacological option to reduce surgical blood loss in total joint arthroplasty is the use of tranexamic acid. Abundant literature has shown that intravenous and/or topical administration of tranexamic acid is effective in reducing blood loss and blood transfusions, with no increased risk of venous thromboembolic events or other complications.

Keywords: tranexamic acid, total hip arthroplasty, total knee arthroplasty, antifibrinolytic, blood transfusion, blood loss

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