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Towards Precision Medicine in Systemic Lupus Erythematosus

Authors Lever E, Alves MR, Isenberg DA

Received 29 October 2019

Accepted for publication 14 January 2020

Published 4 February 2020 Volume 2020:13 Pages 39—49

DOI https://doi.org/10.2147/PGPM.S205079

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Martin H. Bluth


Elliott Lever,1 Marta R Alves,2 David A Isenberg1

1Centre for Rheumatology, Division of Medicine, University College Hospital London, London, UK; 2Internal Medicine, Department of Medicine, Centro Hospitalar do Porto, Porto, Portugal

Correspondence: David A Isenberg
Centre for Rheumatology, Division of Medicine, University College Hospital London, Room 424, the Rayne Building, 5 University Street, London WC1E 6JF, UK
Email d.isenberg@ucl.ac.uk

Abstract: Systemic lupus erythematosus (SLE) is a remarkable condition characterised by diversity amongst its clinical features and immunological abnormalities. In this review, we attempt to capture the major immunological changes linked to the pathophysiology of lupus and discuss the challenge it presents in moving towards the concept of precision medicine. Currently broadly similar types of drugs, e.g., steroids, immunosuppressives, hydroxychloroquine are used to treat many of the diverse clinical features of SLE. We suspect that, as the precise immunopathological abnormalities differ between the various organs/systems in lupus patients, it will be some time before precision medicine can be fully applied to SLE.

Keywords: systemic lupus erythematosus, anti-DNA antibodies, lupus nephritis, lupus genetics, immunosuppression

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