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Topical difluprednate for the treatment of Harada’s disease

Authors Onishi S, Asahi M, Chou C, Gallemore R

Received 20 August 2014

Accepted for publication 16 October 2014

Published 21 January 2015 Volume 2015:9 Pages 157—167

DOI https://doi.org/10.2147/OPTH.S72955

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Scott Fraser


Spencer M Onishi, Masumi G Asahi, Calvin Chou, Ron P Gallemore

Retina Macula Institute, Torrance, CA, USA

Purpose: To describe the use of topical difluprednate for treatment of patients who presented with Harada’s disease.
Methods: Retrospective case series of patients managed with topical difluprednate alone at the onset of the diagnosis. The patients were followed with optical coherence tomography (OCT) and fluorescein angiography.
Results: In our three cases, complete resolution of the exudative detachments with improvement in visual acuity was achieved in each case. Central macular thickness was reduced by a mean of 365±222 µm. Initial loading dose was one drop every hour while awake, followed by a variable tapering regimen. Leakage on fluorescein angiography and exudative detachments on OCT both responded to treatment with difluprednate. In two of the three cases, the patients recovered vision to 20/20, and the third case recovered to 20/25. Steroid-induced glaucoma was observed and managed with one to two glaucoma drops as needed.
Conclusion: Difluprednate is effective for managing ocular manifestations of Harada’s disease. Further studies of this drug for the management of noninfectious posterior uveitis are warranted.

Keywords: serous retinal detachment, noninfectious posterior uveitis, steroid

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