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Titanate nanowire scaffolds decorated with anatase nanocrystals show good protein adsorption and low cell adhesion capacity

Authors Ding XL, Yang XQ, Zhou L, Lu HB, Li SB, Gao Y, Lai CH, Jiang Y

Received 26 October 2012

Accepted for publication 2 December 2012

Published 7 February 2013 Volume 2013:8(1) Pages 569—579

DOI https://doi.org/10.2147/IJN.S39593

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Xianglong Ding,1 Xiaoqin Yang,2 Lei Zhou,1 Haibin Lu,1 Shaobing Li,1 Yan Gao,1 Chunhua Lai,1 Ying Jiang1

1Center of Oral Implantology, 2Department of Oral and Maxillofacial Surgery, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou, People's Republic of China

Background and methods: In this report, layered microporous titanate nanowire scaffolds (TiNWs) were constructed via a hydrothermal route and then decorated with anatase nanocrystals (ANs@TiNWs) by immersion in TiCl4 solution. The diameter and specific surface area of the ANs@TiNWs was measured. The TiNWs and ANs@TiNWs were then compared for their ability to adsorb protein and adhere to MG63 cells.
Results: The diameter and specific surface area of the ANs@TiNWs were significantly larger than for TiNWs, and the ANs@TiNWs had an enhanced protein-adsorbing effect. It was found that the MG63 cells were less able to adhere to the flat titanium substrate than the TiNWs and ANs@TiNWs, and that this cell-repellant ability was greater with ANs@TiNWs. Other MG63 cell functions, proliferation in particular, were also inhibited by ANs@TiNWs.
Conclusion: ANs@TiNWs show a high protein adsorption and cell-repellant capacity which would be useful in drug delivery.

Keywords: protein adsorption, antiadhesion, nanotopography, drug delivery

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