Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 15

Tissue-Specific Ultra-Short Telomeres in Chronic Obstructive Pulmonary Disease

Authors Cagsin H, Uzan A, Tosun O, Rasmussen F, Serakinci N

Received 16 July 2020

Accepted for publication 23 September 2020

Published 30 October 2020 Volume 2020:15 Pages 2751—2757

DOI https://doi.org/10.2147/COPD.S267799

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Richard Russell


Huseyin Cagsin,1,2 Ali Uzan,3 Ozgur Tosun,4 Finn Rasmussen,3,5 Nedime Serakinci1,2

1Department of Medical Genetics, Faculty of Medicine, Near East University, Nicosia, Cyprus; 2Department of Molecular Biology of Genetics, Arts and Sciences Faculty, Near East University, Nicosia, Cyprus; 3Department of Allergy Sleep and Respiratory Medicine, Near East University Hospital, Nicosia, Cyprus; 4Department of Biostatistics, Faculty of Medicine, Near East University, Nicosia, Cyprus; 5Section of Respiratory Medicine; Department of Internal Medicine, Sydvestjysk Hospital, Esbjerg, Denmark

Correspondence: Nedime Serakinci
Near East University, Faculty of Medicine, Department of Medical Genetics, Nicosia 999058, North Cyprus Tel +90 392 675 1000 Ext 3017
Email nedime.serakinci@neu.edu.tr

Purpose: Telomere biology, especially tissue-specific ultra-short telomeres, might provide a strong contribution to our current knowledge in COPD development as well as a predictive marker for prognosis. To test this hypothesis, we investigated telomere lengths in lung tissue and leukocytes in patients diagnosed with COPD.
Patients and Methods: Thirty-two patients were included in the current study. All patients showed a post-bronchodilator ratio of less than 70% post-bronchodilator predicted value of forced expiratory volume in second (FEV1%), mean 56%; range [19% to 86%]. To be able to investigate ultra-short telomeres, universal single telomere length analysis (U-STELA) was used.
Results: Our results showed a higher level of the ultra-short telomere presence in bronchoalveolar lavage (BAL) cells when compared to leukocytes with statistical significance t(62)=5.771, p< 0.00001. The FEV1% was lower in subjects with ultra-short telomeres in BAL (50.6% vs 81.6%: p< 0.001) and in ultra-short telomeres in blood leukocytes (37.3% vs 58.5%: p=0.051) when compared to subjects without ultra-short telomeres in leukocytes. Furthermore, the patients who had ultra-short telomeres in BAL samples were significantly older (p=0.014) than patients who did not have ultra-short telomeres. Ultra-short telomeres in BAL (p=0.05) but not in leukocytes (p=0.33) were associated with FEV1% in a regressions model adjusting for age (p< 0.0001), ever smoking (p< 0.0001) and sex (p=0.71). The patients with ultra-short telomeres were graded higher in the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification (p=0.006).
Conclusion: This study emphasizes the need to investigate the correct tissue to get a representative evaluation of the stage or advancedness of COPD. To our knowledge, this is the first study to show that there is a correlation between the presence of ultra-short telomeres in lung tissue and COPD severity. Our results suggest that ultra-short telomeres are involved in the molecular pathogenesis of COPD and might be used as a tissue-specific predictive biomarker.

Keywords: COPD, ultra-short telomeres, BAL, tissue-specific

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]