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Tissue plasminogen activator (tPA) in the management of predominantly hemorrhagic age-related macular degeneration, milligram/milliliter or microgram/milliliter?

Authors Boone, van Leeuwen RWF

Received 9 November 2011

Accepted for publication 10 November 2011

Published 19 January 2012 Volume 2012:6 Pages 145—146


Niels Willem Boone, Roelof Wouter Frederik van Leeuwen
Maastricht University Medical Centre, Department of Clinical Pharmacy and Toxicology, Maastricht, The Netherlands

Recently our hospital pharmacy, which serves an academic hospital with an internationally well-known department of ophthalmology, received a request for the aseptic preparation of an alteplase syringe solution for subretinal administration. Looking for dose rationale, our ophthalmology doctor came up with a concentration based on an article published by Arias and colleagues in Clinical Ophthalmology in 2010.

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