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Tip of the Iceberg: Roles of CircRNAs in Cancer Glycolysis

Authors Li T, Xian H, Dai L, Tang Y, Liang X

Received 13 December 2020

Accepted for publication 24 March 2021

Published 7 April 2021 Volume 2021:14 Pages 2379—2395

DOI https://doi.org/10.2147/OTT.S297140

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr William Cho


Tan Li,1 Hong-chun Xian,2 Li Dai,1 Ya-ling Tang,2 Xin-hua Liang1

1State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, People’s Republic of China; 2State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu, People’s Republic of China

Correspondence: Ya-ling Tang Tel +86 15008458098
Fax +86 28-86060114
Email [email protected]
Xin-hua Liang Tel +86 15884483965
Fax +86 28-86060114
Email [email protected]

Abstract: Warburg effect reflects that tumor cells tend to generate energy by aerobic glycolysis rather than oxidative phosphorylation (OXPHOS), thus promoting the development of malignant tumors. As a kind of non-coding RNA, circular RNA (circRNA) is characterized by a closed ring structure and emerges as a regulator of cancer metabolism. Mounting studies revealed that circRNA can regulate the cancer metabolism process through affecting the expression of glycolysis relevant enzymes, transcription factors (TFs), and signaling pathways. In this review, we comprehensively analyzed and concluded the mechanism of circRNA regulating glycolysis, hoping to deepen the cognition of the cancer metabolic regulatory network and to reap huge fruits in targeted cancer treatment.

Keywords: cancer, circRNAs, Warburg effect, glucose metabolism

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