Back to Journals » Clinical and Experimental Gastroenterology » Volume 3

Time trends in incidence of peptic ulcer bleeding and associated risk factors in Norway 1985–2008

Authors Bakkevold K

Published 29 June 2010 Volume 2010:3 Pages 71—77

DOI https://doi.org/10.2147/CEG.S10921

Review by Single anonymous peer review

Peer reviewer comments 4


Kåre E Bakkevold

Department of Surgery, Haugesund Hospital, Haugesund, Norway

Objective: The aim of this study was to examine time trends in the incidence of peptic ulcer bleeding and risk factors in a defined geographical area in Norway.

Material and methods: Retrospective data were collected for 306 patients with bleeding peptic ulcers admitted to one hospital during the 1985–1986, 1995–1996, and 2007–2008 periods.

Results: The incidence in 1985–1986 was 52/100,000 and in 2007–2008 was 45/100,000. In the group aged 20–75 years, the incidence decreased by 54% from 54/100000 in 1985–1986 to 25/100000 in 2007–2008 (P = 0.001) and increased by 49% in the group aged >75 years from 272/100000 to 406/100000 (P = 0.0001). The use of aspirin or nonsteroidal anti-inflammatory steroid drugs (NSAIDs) was 31% in 1985–1986 and increased to 67% in 2007–2008 (P = 0.004). In patients using aspirin or NSAIDs, Helicobacter pylori was present in 73% in 1995–1996 and in 51% in 2007–2008. H. pylori infection declined from 84% to 52% between 1995–1996 and 2007–2008.

Conclusions: The incidence rate of peptic ulcer bleeding did not change between 1985–1986 and 2007–2008, but decreased in the age group ≤75 years and increased in the age group >75 years. The use of low-dose aspirin and NSAIDs increased substantially over time, and H. pylori infection was still present in 51% of these patients in 2007–2008.
Keywords: epidemiology, peptic ulcer bleeding, time trends, risk factors

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]