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Time Trends And Age-Period-Cohort Effects On The Incidence Of Gastric Cancer In Changle From 2003 To 2012

Authors Lin Y, Lin S, Chen J, Chen L, Tao T, Wu S

Received 19 April 2019

Accepted for publication 25 July 2019

Published 10 October 2019 Volume 2019:11 Pages 8885—8892

DOI https://doi.org/10.2147/CMAR.S212899

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Professor Rudolph Navari


Yongtian Lin,1,* Shaowei Lin,2,* Jianshun Chen,3 Lici Chen,3 Tao Tao,2 Siying Wu2

1Department of Epidemiology, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fu Zhou, People’s Republic of China; 2Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fu Zhou, People’s Republic of China; 3Department of Office, Changle Cancer Research Institute, Fu Zhou, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Siying Wu
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, No. 1 Xuefu North Road, University Town, Fu Zhou 350122, People’s Republic of China
Tel +86 591 22862510
Fax +86 591 88783929
Email fmuwsy@163.com

Purpose: Although the incidence of gastric cancer in China has declined over the past decades, they were still much higher than the average of global. This aim of this study was to describe the trends and age-period-cohort effects on gastric cancer incidence from 2003 to 2012 in Changle and to explore the potential reason.
Materials and methods: Data on patients with gastric cancer diagnosed between 2003 and 2012 were collected by the population-based Changle cancer registration (n=4111). Age-standardized incidence rates of gastric cancer were calculated and joinpoint regression was used to evaluate the trends of gastric cancer incidence. Time trends in gastric cancer incidence by the period of diagnosis and birth cohort were analyzed by sex. Age-period-cohort analysis was performed to investigate the independent effects of age, period of diagnosis and birth cohort among over 25-year-old residents.
Results: A steady downward trend was observed among men, with the incidence ranging from 96.15 per 100,000 in 2003 to 62.6 per 100,000 in 2012 (APC, −5.1%; 95% CI: −6.9 to −3.2%). A similarly declining trend was observed among women with the incidence ranging from 34.5 per 100,000 to 15.7 per 100,000 (APC, −5.7%; 95% CI: −9.3 to −2.0%). Age-period-cohort model of incidence rate showed increasing age effect and decreasing period of diagnosis effects in both men and women. Birth cohorts exhibited a decreasing trend in the incidence among women who were born after 1935 and men after 1940.
Conclusion: Recent decreases in the incidence of gastric cancer were due to decreased period of diagnosis and cohort effects, which was attributed to the improvements in their lifestyle and habits.

Keywords: gastric cancer, incidence, trend, age-period-cohort model

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